Spontaneous intracerebral hemorrhage as presentation of atypical central neurocytoma: The role of angiogenesis through the characterization of tumor endothelial cells

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A 36-year-old white man presented with sudden-onset headache and rapid deterioration of consciousness. Computer tomography revealed a right capsular intra-parenchimal hemorrhage with an intraventricular component; therefore, emergency surgery was performed. Once the hematoma was evacuated, the cause of the hemorrhage was identified as a tumor mass and it was resected. Histopathological and immunohistochemical examinations of the surgical specimen disclosed a diagnosis of atypical central neurocytoma. By using a protocol recently set up in our laboratory, we succeeded in isolating and propagating, for the first time, human endothelial cells from central neurocytoma (CN-ECs). Different analyses revealed that isolated CN-ECs consist of a pure endothelial cell population, with the expression of endothelial markers (CD31, CD309/VEGFR2, CD105, eNOS) and with angiogenic properties, such as the uptake of LDL. Moreover, CN-ECs spontaneously organize in a vascular-like structure. The goal of this case report is to stress the need for further studies focused on understanding the causes of the onset of an intra-parenchimal hemorrhage in the presence of an atypical central neurocytoma in order to tailor treatments to each single patient and achieve the best clinical outcome.

Original languageEnglish
Pages (from-to)665-672
Number of pages8
JournalHistology and Histopathology
Issue number7
Publication statusPublished - Jul 1 2018



  • Brain tumor
  • Endothelial cells
  • Glioblastoma
  • Neurocytoma
  • Spontaneous intracranial hemorrhage

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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