Spontaneous intracerebral hemorrhage as presentation of atypical central neurocytoma: The role of angiogenesis through the characterization of tumor endothelial cells

Giovani Marfia, Elena Pirola, Stefania Elena Navone, Matteo Beretta, Laura Guarnaccia, Elena Trombetta, Andrea Franzini, Paolo Rampini, Rolando Campanella

Research output: Contribution to journalArticlepeer-review

Abstract

A 36-year-old white man presented with sudden-onset headache and rapid deterioration of consciousness. Computer tomography revealed a right capsular intra-parenchimal hemorrhage with an intraventricular component; therefore, emergency surgery was performed. Once the hematoma was evacuated, the cause of the hemorrhage was identified as a tumor mass and it was resected. Histopathological and immunohistochemical examinations of the surgical specimen disclosed a diagnosis of atypical central neurocytoma. By using a protocol recently set up in our laboratory, we succeeded in isolating and propagating, for the first time, human endothelial cells from central neurocytoma (CN-ECs). Different analyses revealed that isolated CN-ECs consist of a pure endothelial cell population, with the expression of endothelial markers (CD31, CD309/VEGFR2, CD105, eNOS) and with angiogenic properties, such as the uptake of LDL. Moreover, CN-ECs spontaneously organize in a vascular-like structure. The goal of this case report is to stress the need for further studies focused on understanding the causes of the onset of an intra-parenchimal hemorrhage in the presence of an atypical central neurocytoma in order to tailor treatments to each single patient and achieve the best clinical outcome.

Original languageEnglish
Pages (from-to)665-672
Number of pages8
JournalHistology and Histopathology
Volume33
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Keywords

  • Brain tumor
  • Endothelial cells
  • Glioblastoma
  • Neurocytoma
  • Spontaneous intracranial hemorrhage

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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