Spontaneous intracranial hypotension with deep brain swelling

Mario Savoiardo, Ludovico Minati, Laura Farina, Tiziana De Simone, Domenico Aquino, Eliana Mea, Graziella Filippini, Gennaro Bussone, Luisa Chiapparini

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Spontaneous intracranial hypotension (SIH) is caused by leakage of CSF, and characterized on MRI by brain sagging, dilatation of veins and dural sinuses, subdural fluid collections and post-contrast enhancement of the thickened dura. A few cases may present a very severe brain sagging through the tentorial notch and swelling of the diencephalic-mesencephalic structures, with absent or scarce subdural collections and post-contrast enhancement. These patients may have surprisingly few neurological signs or may become drowsy and even lapse into coma due to central herniation. We retrospectively examined the diffusion studies obtained in five patients with these MRI findings, in seven patients with SIH without brain swellings and in ten controls. Mean diffusivity was increased in SIH patients with brain swelling in areas draining into the deep venous system, collected by the vein of Galen (vG) and straight sinus (SS). In the hypothesis that central herniation might be responsible for venous stagnation because of impaired flow of the vG into the SS, the vG/SS angle was measured. The angle formed by the vG entering the SS was not altered in patients without brain swelling (group E, 67.8° ± 10.3°, mean ± SD, range 49-80°) when compared to controls (group C, 73.3° ± 12.3°, mean ± SD, range 56-95°). It was, however, grossly decreased in patients with brain swelling (group D, 40.7° ± 12.8°, mean ± SD, range 22-61°), P <0.001 for comparison with groups E and C. As suggested by previous studies, downward stretching of the vG and narrowing of the vG/SS angle may cause a functional stenosis at the vG-SS junction. We suggest that in the application of the Monro-Kellie doctrine to SIH, the brain volume should not be considered as always invariable.

Original languageEnglish
Pages (from-to)1884-1893
Number of pages10
JournalBrain
Volume130
Issue number7
DOIs
Publication statusPublished - Jul 2007

Fingerprint

Intracranial Hypotension
Cerebral Veins
Brain Edema
Brain
Coma
Dilatation
Veins
Pathologic Constriction
Control Groups

Keywords

  • Diffusion imaging
  • Monro-Kellie doctrine
  • Spontaneous intracranial hypotension
  • Vasogenic oedema
  • Venous stagnation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Savoiardo, M., Minati, L., Farina, L., De Simone, T., Aquino, D., Mea, E., ... Chiapparini, L. (2007). Spontaneous intracranial hypotension with deep brain swelling. Brain, 130(7), 1884-1893. https://doi.org/10.1093/brain/awm101

Spontaneous intracranial hypotension with deep brain swelling. / Savoiardo, Mario; Minati, Ludovico; Farina, Laura; De Simone, Tiziana; Aquino, Domenico; Mea, Eliana; Filippini, Graziella; Bussone, Gennaro; Chiapparini, Luisa.

In: Brain, Vol. 130, No. 7, 07.2007, p. 1884-1893.

Research output: Contribution to journalArticle

Savoiardo, M, Minati, L, Farina, L, De Simone, T, Aquino, D, Mea, E, Filippini, G, Bussone, G & Chiapparini, L 2007, 'Spontaneous intracranial hypotension with deep brain swelling', Brain, vol. 130, no. 7, pp. 1884-1893. https://doi.org/10.1093/brain/awm101
Savoiardo M, Minati L, Farina L, De Simone T, Aquino D, Mea E et al. Spontaneous intracranial hypotension with deep brain swelling. Brain. 2007 Jul;130(7):1884-1893. https://doi.org/10.1093/brain/awm101
Savoiardo, Mario ; Minati, Ludovico ; Farina, Laura ; De Simone, Tiziana ; Aquino, Domenico ; Mea, Eliana ; Filippini, Graziella ; Bussone, Gennaro ; Chiapparini, Luisa. / Spontaneous intracranial hypotension with deep brain swelling. In: Brain. 2007 ; Vol. 130, No. 7. pp. 1884-1893.
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