Spontaneous involution of optic pathway lesions in neurofibromatosis type 1: Serial contrast MR evaluation

C. Parazzini, F. Triulzi, E. Bianchini, V. Agnetti, M. Conti, C. Zanolini, M. M. Maninetti, L. N. Rossi, G. Scotti

Research output: Contribution to journalArticlepeer-review


PURPOSE: To evaluate with contrast MR the evolution in size, signal, and contrast enhancement of optic pathway lesions in four patients with neurofibromatosis type 1. METHODS: The four reported patients are children with ages ranging from 21 months to 13 years affected by neurofibromatosis type 1 and optic pathway lesions. No treatment of the optic pathway lesions was carried out in these patients. They have been followed by serial contrast MR. RESULTS: In all patients a change in size, signal, and enhancement of optic pathways lesions was noted with time, and in the last follow-up study a marked reduction in size and enhancement of optic pathway lesions was observed in all cases. CONCLUSIONS: Modification and regression of optic pathway lesions with spontaneous disappearance of the enhancement is demonstrated. This finding could have a crucial influence on the therapeutic approach of the optic pathway lesions.

Original languageEnglish
Pages (from-to)1711-1718
Number of pages8
JournalAmerican Journal of Neuroradiology
Issue number8
Publication statusPublished - 1995


  • Brain, magnetic resonance
  • Neurofibromatosis
  • Optic tract

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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