INVOLUZIONE SPONTANEA DELLE LESIONI DELLE VIE OTTICHE IN PAZIENTI AFFETTI DA NF-1: VALUTAZIONE SERIATA MEDIANTE RM CON GD-DTPA

Translated title of the contribution: Spontaneous involution of visual pathway lesions in patients with NF-1: Evaluation with MR and GD-DTPA

C. Parazzini, F. Triulzi, V. Agnetti, L. Rossi, E. Bianchini, G. Scotti

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study is to evaluate with contrast MRI the evolution of size, signal and enhancement of the optic-pathway lesions (OPLs) in four patients with NF-1. No treatment of the OPLs was carried out in these patients. In all our cases a change in size, signal and enhancement of OPLs was noted with time and in the last control a clear involution of the OPLs and a dramatic decrease or desappearance of enhancement were detected. The spontaneous regression of lesions that are classified as gliomas is of difficult comprehension in patients without any therapy. Like the intraparenchimalfoci of T2-PDW high signal, that are detected in 60% of patients with NF-1, the OPLs may represent a spectrum of desease and not necessarily neoplastic change. The OPLs could be interpretated as dysplastic lesions and the modification of OPLs enhancement and blood-brain-barrier integrity could represent a different degree of activity of the lesions with a conversion from a reproductive phase to a static one. These acquisitions underline the importance of serial MR examinations and suggest that no aggressive therapy should be undertaken.

Translated title of the contributionSpontaneous involution of visual pathway lesions in patients with NF-1: Evaluation with MR and GD-DTPA
Original languageItalian
Pages (from-to)320-322
Number of pages3
JournalRivista di Neuroradiologia
Volume7
Issue number2
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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