Spontaneous lung metastases in a human lung tumor xenograft: A new experimental model

Cecilia Corti, Graziella Pratesi, Michelandrea De Cesare, Rita Pellegrini, Roberto Giardini, Rosanna Supino, Franco Zunino

Research output: Contribution to journalArticle

Abstract

The cell line NIH-H460, derived from a human large-cell carcinoma of the lung, became metastatic in the lung of athymic mice after s.c. injection. Using serial s.c. passages of the lung metastasis, a cell line was selected, H460M, which was characterized by an increased metastatic potential compared to the parental cells after s.c. (spontaneous metastases) or i.v. injection (experimental metastases). For the high frequency of lung metastases in the mouse and the short time required to develop metastatic foci, the H460M cells transplanted in nude mice represent a unique preclinical model for biological and therapeutic studies. The paper describes the growth and some biological properties (invasion and migration capability, membrane profile) of this experimental in vivo model.

Original languageEnglish
Pages (from-to)154-160
Number of pages7
JournalJournal of Cancer Research and Clinical Oncology
Volume122
Issue number3
DOIs
Publication statusPublished - 1996

Keywords

  • Human tumor xenograft
  • Lung tumor
  • Spontaneous metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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