Spontaneous myocardial calcium oscillations: Overview with emphasis on ryanodine and caffeine

E. G. Lakatta, M. C. Capogrossi, A. A. Kort, M. D. Stern

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

All mammalian cardiac preparations exhibit the capacity for periodic spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) (Ca2+ oscillations). The occurrence of such oscillations in unstimulated preparations and their periodicity depend on the species and the Ca2+ load on the cell. When the spontaneous frequency of these oscillations exceeds the rate of external simulation, they appear between stimulated contractions and impart a variable Ca2+-dependent component of diastolic tonus and a propensity for extrasystoles and arrhythmias to occur; these diastolic oscillations can also affect systolic function as well. Although enhancing the spontaneous frequency of Ca2+ release, caffeine depresses the oscillation amplitude, whereas ryanodine suppresses both frequency and amplitude. Detailed studies of oscillation characteristics and of the different effects of caffeine and ryanodine on them may provide an understanding of and may be useful for modeling SR Ca2+ uptake and release in intact preparations.

Original languageEnglish
Pages (from-to)2977-2983
Number of pages7
JournalFederation Proceedings
Volume44
Issue number15
Publication statusPublished - 1985

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Ryanodine
Calcium Signaling
Sarcoplasmic Reticulum
Caffeine
Premature Cardiac Complexes
Periodicity
Cardiac Arrhythmias

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lakatta, E. G., Capogrossi, M. C., Kort, A. A., & Stern, M. D. (1985). Spontaneous myocardial calcium oscillations: Overview with emphasis on ryanodine and caffeine. Federation Proceedings, 44(15), 2977-2983.

Spontaneous myocardial calcium oscillations : Overview with emphasis on ryanodine and caffeine. / Lakatta, E. G.; Capogrossi, M. C.; Kort, A. A.; Stern, M. D.

In: Federation Proceedings, Vol. 44, No. 15, 1985, p. 2977-2983.

Research output: Contribution to journalArticle

Lakatta, EG, Capogrossi, MC, Kort, AA & Stern, MD 1985, 'Spontaneous myocardial calcium oscillations: Overview with emphasis on ryanodine and caffeine', Federation Proceedings, vol. 44, no. 15, pp. 2977-2983.
Lakatta, E. G. ; Capogrossi, M. C. ; Kort, A. A. ; Stern, M. D. / Spontaneous myocardial calcium oscillations : Overview with emphasis on ryanodine and caffeine. In: Federation Proceedings. 1985 ; Vol. 44, No. 15. pp. 2977-2983.
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