Spontaneous ocular squamous cell carcinoma in twin goats: Pathological and biomolecular studies

M. Marà, G. Di Guardo, A. Venuti, G. Marruchella, C. Palmieri, M. De Rugeriis, L. Petrizzi, P. Simeone, C. Rizzo, L. Della Salda

Research output: Contribution to journalArticlepeer-review

Abstract

Ocular squamous cell carcinoma (OSCC) is a well-characterized tumour occurring spontaneously in cattle and other mammalian species but not previously reported in the goat. This report describes the histological features of well-differentiated OSCCs in twin goats. Biomolecular investigations led to the identification of Papillomavirus-related DNA sequences within the neoplastic ocular parenchyma of both animals, but immunohistochemical and ultrastructural studies failed to demonstrate viral particles. A putative role of Papillomavirus in the aetiology of OSCC is discussed, together with other possible causative factors.

Original languageEnglish
Pages (from-to)96-100
Number of pages5
JournalJournal of Comparative Pathology
Volume132
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • Eye
  • Goat
  • Koilocyte
  • Ocular squamous cell carcinoma
  • Papillomavirus
  • Tumour
  • Viral infection

ASJC Scopus subject areas

  • Animal Science and Zoology

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