Spontaneous pathology of the baboon endocrine system

R. Guardado-Mendoza, E. J. Dick, L. M. Jimenez-Ceja, A. Davalli, A. O. Chavez, F. Folli, G. B. Hubbard

Research output: Contribution to journalArticle

Abstract

Background: Study of endocrine pathology in animal models is critical to understanding endocrine pathology in humans. Methods: We evaluated 434 endocrine-related diagnoses from 4619 baboon necropsies, established the incidence of spontaneous endocrine pathology, and analyzed the clinical and biochemical data associated with the individual cases. Results: The most common diagnoses in descending order, were pancreatic islet cell amyloidosis (n = 259), ovarian cysts (n = 50), pituitary adenoma (n = 37), pancreatic islet cell adenoma (n = 20), granulosa cell tumor (n = 15), thyroid adenoma (n = 11), adrenal hyperplasia (n = 10), thyroid carcinoma (n = 8), and pheochromocytoma (n = 6). The incidence of pancreatic islet cell amyloidosis progressively increased with age. Pheochromocytomas were associated with renal and heart failure. The incidence of pancreatic islet cell amyloidosis and adrenal pathology was similar to humans; the incidence of pituitary adenoma and thyroid pathology was lower than in humans. Conclusions: Endocrine disease in baboons is common and shares clinical and biochemical characteristics with endocrine disease in humans.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalJournal of Medical Primatology
Volume38
Issue number6
DOIs
Publication statusPublished - 2009

Keywords

  • Cancer
  • Disease
  • Endocrine
  • Non-human primate
  • Pancreas
  • Papio
  • Thyroid

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Guardado-Mendoza, R., Dick, E. J., Jimenez-Ceja, L. M., Davalli, A., Chavez, A. O., Folli, F., & Hubbard, G. B. (2009). Spontaneous pathology of the baboon endocrine system. Journal of Medical Primatology, 38(6), 383-389. https://doi.org/10.1111/j.1600-0684.2009.00384.x