Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature

Manolo Piccirilli, Jacopo Lenzi, Catia Delfinis, Guido Trasimeni, Maurizio Salvati, Antonino Raco

Research output: Contribution to journalArticle

Abstract

Case reports: The authors report their experience about three children (two girls, one boy; average age 1.6 years) with a spontaneous regression of optic gliomas. All of them had a previous diagnosis of neurofibromatosis type 1 (NF 1). None of them underwent surgery or biopsy nor received chemotherapy or radiotherapy. The complete regression was documented by MRI scans performed during a mean follow-up of 6.3 years. Literature review: Moreover, the authors analyze the features of the 16 cases previously reported in English literature of spontaneously regressed optic gliomas with an overview of the different therapeutic strategies. The knowledge that this kind of tumor, particularly in young patients, may regress is important in the decision of the best therapeutic approach.

Original languageEnglish
Pages (from-to)1332-1337
Number of pages6
JournalChild's Nervous System
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Magnetic resonance imaging
  • Neurofibromatosis type I
  • Optic gliomas

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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