Spontaneous regression of transplacental metastases from maternal melanoma in a newborn: Case report and review of the literature

Mario Valenzano Menada, Melita Moioli, Alberto Garaventa, Paolo Nozza, Marilena Foppiano, Nadia Trimarchi, Ezio Fulcheri

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman. She was aware of a greyish-brown nodular lesion on the right gluteus during her first pregnancy. On histological examination, this lesion resulted to be an amelanocitic melanoma. Breast metastases occurred during her second pregnancy, 18 months after the surgical excision; an emergency Caesarean section performed for the recrudement of her clinical conditions confirmed widespread metastases to the liver, spleen and peritoneum. The patient died 2 weeks after delivery. The newborn, at 3 months of age, presented metastases secondary to maternal melanoma, which were resistant to chemotherapy. The disease regressed spontaneously and the child is now 24 months, alive in complete remission.

Original languageEnglish
Pages (from-to)443-449
Number of pages7
JournalMelanoma Research
Volume20
Issue number6
DOIs
Publication statusPublished - Dec 2010

Keywords

  • melanoma
  • metastases
  • placenta
  • pregnancy
  • spontaneous regression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Dermatology

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