Spontaneous release of interleukin-1 (IL-1) from medullary mononuclear cells of pagetic subjects

Giulio Pioli, Giuseppe Girasole, Mario Pedrazzoni, Paolo Sansoni, Annalaura Erroi, Luisa Davoli, Giuseppina Ciotti, Alberto Mantovani, Mario Passeri

Research output: Contribution to journalArticlepeer-review

Abstract

The Authors examined interleukin 1 (IL-1) secretion from the peripheral and medullary mononuclear cells, obtained with sequential separation on Ficoll-Hypaque and 45% Percoll gradient, in 6 pagetic subjects and 6 normal controls. Both peripheral and medullary cells from pagetic subjects showed a significantly greater IL-1 production after stimulation with lipopolyshaccarides (LPS); moreover, we observed a spontaneous IL-1 release from medullary cells in pagetic subjects but not in normal controls. These findings suggest a possible role of IL-1 in the elevated bone turnover of Paget's disease of bone.

Original languageEnglish
Pages (from-to)257-259
Number of pages3
JournalCalcified Tissue International
Volume45
Issue number4
DOIs
Publication statusPublished - Jul 1989

Keywords

  • Interleukin 1
  • Mononuclear cells
  • Paget's disease

ASJC Scopus subject areas

  • Endocrinology

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