Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus

Alessandro Stefani, Salvatore Galati, Antonella Peppe, Andrea Bassi, Mariangela Pierantozzi, Atticus H. Hainsworth, Giorgio Bernardi, Antonio Orlacchio, Paolo Stanzione, Paolo Mazzone

Research output: Contribution to journalArticle

Abstract

In Parkinson's disease, the subthalamic nucleus (STN) is a common target for functional neurosurgery. Recent investigations have suggested that physiological non-motor stimuli may dramatically alter STN firing properties. By maintaining long-lasting micro-recordings of STN single units in Parkinson's disease (PD) patients, here we show that the neurons that are responsive to passive movements are also strongly modulated by altered vigilance state (awake vs. sleep). In addition, sleep was characterized by a distinctive irregular train-like firing pattern. These findings suggest that the reduction of the somato-sensory input modifies rigidity and, hence, STN discharge mode. Further, it is suggested that specific STN electrophysiological features are potential targets for future therapeutic interventions.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalExperimental Brain Research
Volume168
Issue number1-2
DOIs
Publication statusPublished - Jan 2006

Fingerprint

Subthalamic Nucleus
Sleep
Parkinson Disease
Neurosurgery
Neurons

Keywords

  • Basal ganglia
  • DBS
  • Firing pattern
  • Parkinson's disease
  • Vigilance

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stefani, A., Galati, S., Peppe, A., Bassi, A., Pierantozzi, M., Hainsworth, A. H., ... Mazzone, P. (2006). Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus. Experimental Brain Research, 168(1-2), 277-280. https://doi.org/10.1007/s00221-005-0175-y

Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus. / Stefani, Alessandro; Galati, Salvatore; Peppe, Antonella; Bassi, Andrea; Pierantozzi, Mariangela; Hainsworth, Atticus H.; Bernardi, Giorgio; Orlacchio, Antonio; Stanzione, Paolo; Mazzone, Paolo.

In: Experimental Brain Research, Vol. 168, No. 1-2, 01.2006, p. 277-280.

Research output: Contribution to journalArticle

Stefani, A, Galati, S, Peppe, A, Bassi, A, Pierantozzi, M, Hainsworth, AH, Bernardi, G, Orlacchio, A, Stanzione, P & Mazzone, P 2006, 'Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus', Experimental Brain Research, vol. 168, no. 1-2, pp. 277-280. https://doi.org/10.1007/s00221-005-0175-y
Stefani, Alessandro ; Galati, Salvatore ; Peppe, Antonella ; Bassi, Andrea ; Pierantozzi, Mariangela ; Hainsworth, Atticus H. ; Bernardi, Giorgio ; Orlacchio, Antonio ; Stanzione, Paolo ; Mazzone, Paolo. / Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus. In: Experimental Brain Research. 2006 ; Vol. 168, No. 1-2. pp. 277-280.
@article{fa049603264c4c5ea942d029b4a0afd3,
title = "Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus",
abstract = "In Parkinson's disease, the subthalamic nucleus (STN) is a common target for functional neurosurgery. Recent investigations have suggested that physiological non-motor stimuli may dramatically alter STN firing properties. By maintaining long-lasting micro-recordings of STN single units in Parkinson's disease (PD) patients, here we show that the neurons that are responsive to passive movements are also strongly modulated by altered vigilance state (awake vs. sleep). In addition, sleep was characterized by a distinctive irregular train-like firing pattern. These findings suggest that the reduction of the somato-sensory input modifies rigidity and, hence, STN discharge mode. Further, it is suggested that specific STN electrophysiological features are potential targets for future therapeutic interventions.",
keywords = "Basal ganglia, DBS, Firing pattern, Parkinson's disease, Vigilance",
author = "Alessandro Stefani and Salvatore Galati and Antonella Peppe and Andrea Bassi and Mariangela Pierantozzi and Hainsworth, {Atticus H.} and Giorgio Bernardi and Antonio Orlacchio and Paolo Stanzione and Paolo Mazzone",
year = "2006",
month = "1",
doi = "10.1007/s00221-005-0175-y",
language = "English",
volume = "168",
pages = "277--280",
journal = "Experimental Brain Research",
issn = "0014-4819",
publisher = "Springer Verlag",
number = "1-2",

}

TY - JOUR

T1 - Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus

AU - Stefani, Alessandro

AU - Galati, Salvatore

AU - Peppe, Antonella

AU - Bassi, Andrea

AU - Pierantozzi, Mariangela

AU - Hainsworth, Atticus H.

AU - Bernardi, Giorgio

AU - Orlacchio, Antonio

AU - Stanzione, Paolo

AU - Mazzone, Paolo

PY - 2006/1

Y1 - 2006/1

N2 - In Parkinson's disease, the subthalamic nucleus (STN) is a common target for functional neurosurgery. Recent investigations have suggested that physiological non-motor stimuli may dramatically alter STN firing properties. By maintaining long-lasting micro-recordings of STN single units in Parkinson's disease (PD) patients, here we show that the neurons that are responsive to passive movements are also strongly modulated by altered vigilance state (awake vs. sleep). In addition, sleep was characterized by a distinctive irregular train-like firing pattern. These findings suggest that the reduction of the somato-sensory input modifies rigidity and, hence, STN discharge mode. Further, it is suggested that specific STN electrophysiological features are potential targets for future therapeutic interventions.

AB - In Parkinson's disease, the subthalamic nucleus (STN) is a common target for functional neurosurgery. Recent investigations have suggested that physiological non-motor stimuli may dramatically alter STN firing properties. By maintaining long-lasting micro-recordings of STN single units in Parkinson's disease (PD) patients, here we show that the neurons that are responsive to passive movements are also strongly modulated by altered vigilance state (awake vs. sleep). In addition, sleep was characterized by a distinctive irregular train-like firing pattern. These findings suggest that the reduction of the somato-sensory input modifies rigidity and, hence, STN discharge mode. Further, it is suggested that specific STN electrophysiological features are potential targets for future therapeutic interventions.

KW - Basal ganglia

KW - DBS

KW - Firing pattern

KW - Parkinson's disease

KW - Vigilance

UR - http://www.scopus.com/inward/record.url?scp=28644434000&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28644434000&partnerID=8YFLogxK

U2 - 10.1007/s00221-005-0175-y

DO - 10.1007/s00221-005-0175-y

M3 - Article

C2 - 16328297

AN - SCOPUS:28644434000

VL - 168

SP - 277

EP - 280

JO - Experimental Brain Research

JF - Experimental Brain Research

SN - 0014-4819

IS - 1-2

ER -