Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata

Bruno Azzarone, Delfina Pedullà

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Stromal fibroblasts derived from human tumours have been always considered normal cells. In this report it is shown that fibroblasts derived from lung cancers, regularly under go spontaneous transformation when cultured in crowded growth conditions, while fibroblasts derived from non-neoplastic tissues do not transform. This particular behaviour may reflect a preneoplastic state of stromal fibroblasts derived from lung cancers.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalEuropean Journal of Cancer (1965)
Issue number7
Publication statusPublished - 1976


ASJC Scopus subject areas

  • Oncology

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