Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata

Bruno Azzarone, Delfina Pedullà

Research output: Contribution to journalArticle

Abstract

Stromal fibroblasts derived from human tumours have been always considered normal cells. In this report it is shown that fibroblasts derived from lung cancers, regularly under go spontaneous transformation when cultured in crowded growth conditions, while fibroblasts derived from non-neoplastic tissues do not transform. This particular behaviour may reflect a preneoplastic state of stromal fibroblasts derived from lung cancers.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalEuropean Journal of Cancer (1965)
Volume12
Issue number7
DOIs
Publication statusPublished - 1976

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ASJC Scopus subject areas

  • Oncology

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