Spontaneous variability of regional haemodynamics in unanaesthetized rats

Alberto U. Ferrari, Anna Daffonchio, Silvia Gerosa, Cristina Franzelli, Paolo Paleari, Calogero Ventura, Marco DiRienzo, Giuseppe Mancia

Research output: Contribution to journalArticle

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Abstract

Aim: To study the spontaneous variability in regional haemodynamics. Methods: Twenty normotensive Wistar-Kyoto rats were chronically instrumented with an arterial catheter and with pulsed Doppler flowmeters on the distal aorta, and the superior mesenteric and left renal arteries. After surgical recovery, the rats were monitored in unrestrained conditions. The recordedsignals were analysed beat-to-beat to obtain means and coefficients of variation for mean arterial pressure, heart rate, regional blood flow velocity (consecutive 0.8-s periods) and indices of regional vascular resistance (0.8-s ratio of mean arterial pressure to mean blood flow velocity). Results: Muscle and splanchnic blood flow velocities were markedly variable, with coefficients of variation of 12.8 ±0.8 and 12.2 ±1.7% (means ±SEM), respectively, about twice as large as the coefficient of variation for mean arterial pressure (6.2 ±0.3%). The renal blood flow velocity was slightly less variable than the muscle and splanchnic blood flow velocities, with a coefficient of variationof 10.4 ±0.8%, but still markedly and significantly more variable than systemic arterial pressure. A contingency analysis of paired variations in any two given parameters (arterial blood pressure, heart rate, blood flow velocities and indices of vascular resistance) showed a concordant pattern,the only exception being a distinctly discordant trend for the covariations in muscle and splanchnic blood flow velocities. Conclusions: Regional blood flow velocity and vascular resistance have a larger degree of spontaneous variability than systemic arterial pressure. Renal blood flow velocityisalso highly variable, suggesting that short-term stimuli that affect the renal blood vessels are not countered by autoregulation to any great degree.Weconclude that while central factors may drive concordant regional haemodynamic variations, some opposing changes in regional blood flow velocity may cancel each other out, thereby reducing the variability in systemic blood pressure.

Original languageEnglish
Pages (from-to)535-536
Number of pages2
JournalJournal of Hypertension
Volume11
Issue number5
Publication statusPublished - 1993

Fingerprint

Blood Flow Velocity
Hemodynamics
Arterial Pressure
Viscera
Regional Blood Flow
Vascular Resistance
Renal Circulation
Muscles
Heart Rate
Flowmeters
Inbred WKY Rats
Renal Artery
Blood Vessels
Aorta
Homeostasis
Catheters
Blood Pressure
Kidney

Keywords

  • Blood pressure variability
  • Neural cardiovascular control
  • Regional blood flow
  • Regional haemodynamics
  • Renal autoregulation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

Cite this

Ferrari, A. U., Daffonchio, A., Gerosa, S., Franzelli, C., Paleari, P., Ventura, C., ... Mancia, G. (1993). Spontaneous variability of regional haemodynamics in unanaesthetized rats. Journal of Hypertension, 11(5), 535-536.

Spontaneous variability of regional haemodynamics in unanaesthetized rats. / Ferrari, Alberto U.; Daffonchio, Anna; Gerosa, Silvia; Franzelli, Cristina; Paleari, Paolo; Ventura, Calogero; DiRienzo, Marco; Mancia, Giuseppe.

In: Journal of Hypertension, Vol. 11, No. 5, 1993, p. 535-536.

Research output: Contribution to journalArticle

Ferrari, AU, Daffonchio, A, Gerosa, S, Franzelli, C, Paleari, P, Ventura, C, DiRienzo, M & Mancia, G 1993, 'Spontaneous variability of regional haemodynamics in unanaesthetized rats', Journal of Hypertension, vol. 11, no. 5, pp. 535-536.
Ferrari AU, Daffonchio A, Gerosa S, Franzelli C, Paleari P, Ventura C et al. Spontaneous variability of regional haemodynamics in unanaesthetized rats. Journal of Hypertension. 1993;11(5):535-536.
Ferrari, Alberto U. ; Daffonchio, Anna ; Gerosa, Silvia ; Franzelli, Cristina ; Paleari, Paolo ; Ventura, Calogero ; DiRienzo, Marco ; Mancia, Giuseppe. / Spontaneous variability of regional haemodynamics in unanaesthetized rats. In: Journal of Hypertension. 1993 ; Vol. 11, No. 5. pp. 535-536.
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AU - Gerosa, Silvia

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AU - Paleari, Paolo

AU - Ventura, Calogero

AU - DiRienzo, Marco

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N2 - Aim: To study the spontaneous variability in regional haemodynamics. Methods: Twenty normotensive Wistar-Kyoto rats were chronically instrumented with an arterial catheter and with pulsed Doppler flowmeters on the distal aorta, and the superior mesenteric and left renal arteries. After surgical recovery, the rats were monitored in unrestrained conditions. The recordedsignals were analysed beat-to-beat to obtain means and coefficients of variation for mean arterial pressure, heart rate, regional blood flow velocity (consecutive 0.8-s periods) and indices of regional vascular resistance (0.8-s ratio of mean arterial pressure to mean blood flow velocity). Results: Muscle and splanchnic blood flow velocities were markedly variable, with coefficients of variation of 12.8 ±0.8 and 12.2 ±1.7% (means ±SEM), respectively, about twice as large as the coefficient of variation for mean arterial pressure (6.2 ±0.3%). The renal blood flow velocity was slightly less variable than the muscle and splanchnic blood flow velocities, with a coefficient of variationof 10.4 ±0.8%, but still markedly and significantly more variable than systemic arterial pressure. A contingency analysis of paired variations in any two given parameters (arterial blood pressure, heart rate, blood flow velocities and indices of vascular resistance) showed a concordant pattern,the only exception being a distinctly discordant trend for the covariations in muscle and splanchnic blood flow velocities. Conclusions: Regional blood flow velocity and vascular resistance have a larger degree of spontaneous variability than systemic arterial pressure. Renal blood flow velocityisalso highly variable, suggesting that short-term stimuli that affect the renal blood vessels are not countered by autoregulation to any great degree.Weconclude that while central factors may drive concordant regional haemodynamic variations, some opposing changes in regional blood flow velocity may cancel each other out, thereby reducing the variability in systemic blood pressure.

AB - Aim: To study the spontaneous variability in regional haemodynamics. Methods: Twenty normotensive Wistar-Kyoto rats were chronically instrumented with an arterial catheter and with pulsed Doppler flowmeters on the distal aorta, and the superior mesenteric and left renal arteries. After surgical recovery, the rats were monitored in unrestrained conditions. The recordedsignals were analysed beat-to-beat to obtain means and coefficients of variation for mean arterial pressure, heart rate, regional blood flow velocity (consecutive 0.8-s periods) and indices of regional vascular resistance (0.8-s ratio of mean arterial pressure to mean blood flow velocity). Results: Muscle and splanchnic blood flow velocities were markedly variable, with coefficients of variation of 12.8 ±0.8 and 12.2 ±1.7% (means ±SEM), respectively, about twice as large as the coefficient of variation for mean arterial pressure (6.2 ±0.3%). The renal blood flow velocity was slightly less variable than the muscle and splanchnic blood flow velocities, with a coefficient of variationof 10.4 ±0.8%, but still markedly and significantly more variable than systemic arterial pressure. A contingency analysis of paired variations in any two given parameters (arterial blood pressure, heart rate, blood flow velocities and indices of vascular resistance) showed a concordant pattern,the only exception being a distinctly discordant trend for the covariations in muscle and splanchnic blood flow velocities. Conclusions: Regional blood flow velocity and vascular resistance have a larger degree of spontaneous variability than systemic arterial pressure. Renal blood flow velocityisalso highly variable, suggesting that short-term stimuli that affect the renal blood vessels are not countered by autoregulation to any great degree.Weconclude that while central factors may drive concordant regional haemodynamic variations, some opposing changes in regional blood flow velocity may cancel each other out, thereby reducing the variability in systemic blood pressure.

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