Sporadic desmoid tumors of the abdominal wall: The results of surgery

Chiara Erminia Mussi, Piergiuseppe Colombo, Lo Russo Chiara, Anaid Kasangian, Ferdinando Carlo Maria Cananzi, Andrea Marrari, Emanuela Morenghi, Rita De Sanctis, Vittorio Quagliuolo

Research output: Contribution to journalArticlepeer-review


Purpose: Before the wait-and-see policy became the standard approach in abdominal wall desmoid tumors, surgery was performed on a systematic basis. Surgery remains indicated for progressing tumors but its extent is debatable. The abdominal wall is a common site of origin of sporadic desmoids, usually associated with a favorable prognosis. We analyzed the results of surgery at this specific site. Methods: Data from 33 patients affected by sporadic desmoid tumors of the abdominal wall (31 primary, 2 recurrent) consecutively treated at our cancer center between January 2000 and September 2013 were retrospectively studied. Results: Twenty-nine patients underwent surgery upfront and 1 after progression during the initial wait-and-see period. Prosthetic reconstruction of the abdominal wall was required in 28 patients. The average hospital stay was 5 days. Three patients developed surgical complications. Local recurrence-free survival was 90% at 5 and 10 years. Three patients had an uneventful childbirth during the follow-up after surgery. Conclusions: Desmoid tumors of the abdominal wall have a favorable prognosis after surgical resection, which remains a safe and effective treatment. Wild-type tumors are common, whereas the incidence of S45F mutation in the beta-catenin gene is lower than in other anatomic sites. Upfront surgery may be considered in selected women who wish to bear a child.

Original languageEnglish
Pages (from-to)582-587
Number of pages6
Issue number6
Publication statusPublished - Nov 1 2016


  • Aggressive fibromatosis
  • Beta-catenin mutation
  • Desmoid tumor
  • Pregnancy
  • S45F mutation
  • Tumor of abdominal wall

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research


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