Sporadic Hepatitis C virus infection: A case-control study of transmission routes in a selected hospital sample of the general population in Italy

Ubaldo Visco Comandini, Gianna Tossini, Maria Antonella Longo, Fabrizio Ferri, Gilda Cuzzi, Pasquale Noto, Mauro Zaccarelli, Giuseppe Visco

Research output: Contribution to journalArticle

Abstract

A case-control study was performed on 9,175 Italian adult outpatients in 5 hospitals in Rome. The study was carried out to clarify the role of some less investigated risk factors (RF) in the spread of hepatitis C virus (HCV) infection. All subjects were contacted by interviewers, who completed a questionnaire. Their sera were stored and subsequently tested for both HCV and hepatitis B virus core (HBc) antibodies. 365 subjects, positive for anti-HCV and anti-HBc-negative, and who had denied intravenous drug use (IDU) (cases) were compared with an equal number of suitable random controls negative for anti-HCV and anti-HBc. Gender, age and region of birth and residence mere matched. The prevalence of 13 RFs were statistically compared by univariate and multivariate analysis. A positive anti-HCV test was significantly associated, by multivariate analysis with intravenous treatments and minor surgical procedures (both before 1975) (p <0.001), blood transfusions (before 1991) (p <0.01), diabetes (p <0.01), and deliveries in hospital (p <0.05) (both before 1975). After 1975 (1991 for transfusions), all associations lost their significance. Intra-familial (sexual and non sexual), occupational RFs and dental care were not significantly associated with the presence of anti-HCV. We suggest that non-disposable syringes, commonly used until 1975 in Italy for i.v. treatments, have been the major route for HCV transmission in Italy among non-IDU subjects.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalScandinavian Journal of Infectious Diseases
Volume30
Issue number1
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

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