Human sebum is renowned as a unique mixture of lipids. Although the complexity of human sebum composition is suggestive of the multiplicity of sebum functions, squalene deserves a special focus due to its extraordinary abundance on human skin. Noteworthy, squalene is the main standalone and unsaponifiable component in sebum. The majority of sebaceous lipid components are members of lipid families, such as fatty acids (FA), triglycerides (TG), wax esters (WE), and cholesterol esters (CE). In particular, TG together with free FA account for the 40–60 % of the sebum weight, followed by WE (19–26 %), and squalene (10–15 %). Although minimal amounts of cholesterol are measurable in sebum, its exact origin is still unclear.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)