Squalene peroxides may contribute to ultraviolet light-induced immunological effects

M. Picardo, C. Zompetta, C. De Luca, A. Amantea, A. Faggioni, M. Nazzaro-Porro, S. Passi

Research output: Contribution to journalArticle

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Abstract

Ultraviolet (UV) irradiation is capable of producing a dose-dependent decomposition of skin surface lipids and particularly of squalene, with the concomitant generation of active lipoperoxides. The biological effects of UV-peroxidated squalene were tested, compared with those produced by synthetic lipoperoxides (cumene hydroperoxide), on some immunological parameters in vivo modified by UVB irradiation. Application of UV-peroxidated squalene as well as cumene hydroperoxide significantly inhibited the induction of contact hypersensitivity to dinitrofluorobenzene in mice, which was associated with a decrease in the number of ATPase positive cells. The effect was dose-dependent (over 40 μg for peroxidated squalene and over 20 μg for cumene) and relevant after 2 d of treatment. Down-regulation towards the applied hapten was demonstrated. The results indicate that UV-induced lipoperoxides of squalene are capable of inhibiting the induction of contact hypersensitivity in mice and suggest that, among the other photoproducts generated in humans, squalene peroxides may play a role as biochemical messengers of the biological effects of UV irradiation of the skin.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalPhotodermatology Photoimmunology and Photomedicine
Volume8
Issue number3
Publication statusPublished - 1991

Fingerprint

Squalene
Ultraviolet Rays
Lipid Peroxides
Contact Dermatitis
Dinitrofluorobenzene
Skin
Haptens
Adenosine Triphosphatases
Down-Regulation
2,3-oxidosqualene
Lipids

ASJC Scopus subject areas

  • Immunology
  • Dermatology

Cite this

Picardo, M., Zompetta, C., De Luca, C., Amantea, A., Faggioni, A., Nazzaro-Porro, M., & Passi, S. (1991). Squalene peroxides may contribute to ultraviolet light-induced immunological effects. Photodermatology Photoimmunology and Photomedicine, 8(3), 105-110.

Squalene peroxides may contribute to ultraviolet light-induced immunological effects. / Picardo, M.; Zompetta, C.; De Luca, C.; Amantea, A.; Faggioni, A.; Nazzaro-Porro, M.; Passi, S.

In: Photodermatology Photoimmunology and Photomedicine, Vol. 8, No. 3, 1991, p. 105-110.

Research output: Contribution to journalArticle

Picardo, M, Zompetta, C, De Luca, C, Amantea, A, Faggioni, A, Nazzaro-Porro, M & Passi, S 1991, 'Squalene peroxides may contribute to ultraviolet light-induced immunological effects', Photodermatology Photoimmunology and Photomedicine, vol. 8, no. 3, pp. 105-110.
Picardo, M. ; Zompetta, C. ; De Luca, C. ; Amantea, A. ; Faggioni, A. ; Nazzaro-Porro, M. ; Passi, S. / Squalene peroxides may contribute to ultraviolet light-induced immunological effects. In: Photodermatology Photoimmunology and Photomedicine. 1991 ; Vol. 8, No. 3. pp. 105-110.
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