Squamocellular Carcinoma of the Skin: Clinicopathological Features Predicting the Involvement of the Surgical Margins and Review of the Literature

Simone Ribero, Simona Osella Abate, Chiara Di Capua, Emi Dika, Elena Balagna, Rebecca Senetta, Franco Picciotto, Carlo Tomasini, Giuseppe Macripo, Pietro Quaglino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The new AJCC classification has highlighted some particular risk factors for squamous cell carcinoma (SCC) relevant for prognosis. Incomplete excision is not infrequent in SCC. The aim of this study is to examine features that can predict an incomplete excision on the basis of the new AJCC classification and to review the literature on this topic. Materials and Methods: 81 SCC patients were included. All patients were submitted to excisional biopsy with a margin of at least 4 mm from the clinical edges as recommended. Histological characteristics of the lesions analysed were maximum diameter, grading, site, Breslow thickness, Clark level, deep tissue invasion (neural, bone, muscle), presence of ulceration and positivity of the margins. Results: The average Breslow thickness was 3.93 mm. Out of the 81 patients included, 14 showed involved margins. The 2 parameters that were implicated in predicting involvement of the margins in the multivariable model were Breslow thickness and location of the lesion on the ear or lip. Grading was not associated with involvement of margins. Conclusion: According to the new AJCC classification, this study could be useful to plan the most suitable surgical technique in order to avoid the risk of incomplete surgery.

Original languageEnglish
JournalDermatology
DOIs
Publication statusAccepted/In press - Mar 31 2016

Fingerprint

Squamous Cell Carcinoma
Carcinoma
Skin
Lip
Ear
Biopsy
Bone and Bones
Muscles
Margins of Excision

Keywords

  • Margin excision
  • Squamocellular carcinoma
  • Surgery#

ASJC Scopus subject areas

  • Dermatology

Cite this

Squamocellular Carcinoma of the Skin : Clinicopathological Features Predicting the Involvement of the Surgical Margins and Review of the Literature. / Ribero, Simone; Osella Abate, Simona; Di Capua, Chiara; Dika, Emi; Balagna, Elena; Senetta, Rebecca; Picciotto, Franco; Tomasini, Carlo; Macripo, Giuseppe; Quaglino, Pietro.

In: Dermatology, 31.03.2016.

Research output: Contribution to journalArticle

Ribero, S, Osella Abate, S, Di Capua, C, Dika, E, Balagna, E, Senetta, R, Picciotto, F, Tomasini, C, Macripo, G & Quaglino, P 2016, 'Squamocellular Carcinoma of the Skin: Clinicopathological Features Predicting the Involvement of the Surgical Margins and Review of the Literature', Dermatology. https://doi.org/10.1159/000444051
Ribero, Simone ; Osella Abate, Simona ; Di Capua, Chiara ; Dika, Emi ; Balagna, Elena ; Senetta, Rebecca ; Picciotto, Franco ; Tomasini, Carlo ; Macripo, Giuseppe ; Quaglino, Pietro. / Squamocellular Carcinoma of the Skin : Clinicopathological Features Predicting the Involvement of the Surgical Margins and Review of the Literature. In: Dermatology. 2016.
@article{0fe46bd449a3474ab3402db63d3d8daf,
title = "Squamocellular Carcinoma of the Skin: Clinicopathological Features Predicting the Involvement of the Surgical Margins and Review of the Literature",
abstract = "Background: The new AJCC classification has highlighted some particular risk factors for squamous cell carcinoma (SCC) relevant for prognosis. Incomplete excision is not infrequent in SCC. The aim of this study is to examine features that can predict an incomplete excision on the basis of the new AJCC classification and to review the literature on this topic. Materials and Methods: 81 SCC patients were included. All patients were submitted to excisional biopsy with a margin of at least 4 mm from the clinical edges as recommended. Histological characteristics of the lesions analysed were maximum diameter, grading, site, Breslow thickness, Clark level, deep tissue invasion (neural, bone, muscle), presence of ulceration and positivity of the margins. Results: The average Breslow thickness was 3.93 mm. Out of the 81 patients included, 14 showed involved margins. The 2 parameters that were implicated in predicting involvement of the margins in the multivariable model were Breslow thickness and location of the lesion on the ear or lip. Grading was not associated with involvement of margins. Conclusion: According to the new AJCC classification, this study could be useful to plan the most suitable surgical technique in order to avoid the risk of incomplete surgery.",
keywords = "Margin excision, Squamocellular carcinoma, Surgery#",
author = "Simone Ribero and {Osella Abate}, Simona and {Di Capua}, Chiara and Emi Dika and Elena Balagna and Rebecca Senetta and Franco Picciotto and Carlo Tomasini and Giuseppe Macripo and Pietro Quaglino",
year = "2016",
month = "3",
day = "31",
doi = "10.1159/000444051",
language = "English",
journal = "Dermatology",
issn = "1018-8665",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Squamocellular Carcinoma of the Skin

T2 - Clinicopathological Features Predicting the Involvement of the Surgical Margins and Review of the Literature

AU - Ribero, Simone

AU - Osella Abate, Simona

AU - Di Capua, Chiara

AU - Dika, Emi

AU - Balagna, Elena

AU - Senetta, Rebecca

AU - Picciotto, Franco

AU - Tomasini, Carlo

AU - Macripo, Giuseppe

AU - Quaglino, Pietro

PY - 2016/3/31

Y1 - 2016/3/31

N2 - Background: The new AJCC classification has highlighted some particular risk factors for squamous cell carcinoma (SCC) relevant for prognosis. Incomplete excision is not infrequent in SCC. The aim of this study is to examine features that can predict an incomplete excision on the basis of the new AJCC classification and to review the literature on this topic. Materials and Methods: 81 SCC patients were included. All patients were submitted to excisional biopsy with a margin of at least 4 mm from the clinical edges as recommended. Histological characteristics of the lesions analysed were maximum diameter, grading, site, Breslow thickness, Clark level, deep tissue invasion (neural, bone, muscle), presence of ulceration and positivity of the margins. Results: The average Breslow thickness was 3.93 mm. Out of the 81 patients included, 14 showed involved margins. The 2 parameters that were implicated in predicting involvement of the margins in the multivariable model were Breslow thickness and location of the lesion on the ear or lip. Grading was not associated with involvement of margins. Conclusion: According to the new AJCC classification, this study could be useful to plan the most suitable surgical technique in order to avoid the risk of incomplete surgery.

AB - Background: The new AJCC classification has highlighted some particular risk factors for squamous cell carcinoma (SCC) relevant for prognosis. Incomplete excision is not infrequent in SCC. The aim of this study is to examine features that can predict an incomplete excision on the basis of the new AJCC classification and to review the literature on this topic. Materials and Methods: 81 SCC patients were included. All patients were submitted to excisional biopsy with a margin of at least 4 mm from the clinical edges as recommended. Histological characteristics of the lesions analysed were maximum diameter, grading, site, Breslow thickness, Clark level, deep tissue invasion (neural, bone, muscle), presence of ulceration and positivity of the margins. Results: The average Breslow thickness was 3.93 mm. Out of the 81 patients included, 14 showed involved margins. The 2 parameters that were implicated in predicting involvement of the margins in the multivariable model were Breslow thickness and location of the lesion on the ear or lip. Grading was not associated with involvement of margins. Conclusion: According to the new AJCC classification, this study could be useful to plan the most suitable surgical technique in order to avoid the risk of incomplete surgery.

KW - Margin excision

KW - Squamocellular carcinoma

KW - Surgery#

UR - http://www.scopus.com/inward/record.url?scp=84961989703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961989703&partnerID=8YFLogxK

U2 - 10.1159/000444051

DO - 10.1159/000444051

M3 - Article

AN - SCOPUS:84961989703

JO - Dermatology

JF - Dermatology

SN - 1018-8665

ER -