Squamous cell carcinoma antigen (SCC-Ag) during follow-up of cervical cancer patients: Role in the early diagnosis of recurrence

Michela Salvatici; Maria T. Achilarre; Maria T. Sandri; Sara Boveri; Zanagnolo Vanna; Fabio Landoni

doi:10.1016/j.ygyno.2016.04.029

Squamous cell carcinoma antigen (SCC-Ag) during follow-up of cervical cancer patients: Role in the early diagnosis of recurrence

Michela Salvatici, Maria T. Achilarre, Maria T. Sandri, Sara Boveri, Zanagnolo Vanna, Fabio Landoni

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The aim of this study was to assess the potential benefit of routine squamous cell carcinoma antigen (SCC-Ag) assessment during follow-up of patients after treatment for early cervical cancer with regard to early diagnosis of cancer recurrence before clinical signs and symptoms occur. Methods: All clinical, pathological, and serological data of patients referred to the Department of Gynecologic Oncology between July 1999 and June 2014, were retrospectively collected and analyzed. The SCC-Ag levels of 197 patients with diagnosis of stage I or II cervical squamous carcinoma, were performed. Results: In the univariate analysis, serum SCC-Ag was not significantly associated with grading (p = 0.85), LVSI (p = 0.95) and FIGO stage (p = 0.83) but it was significantly associated with recurrence of disease (p

Original language	English
Journal	Gynecologic Oncology
DOIs	https://doi.org/10.1016/j.ygyno.2016.04.029
Publication status	Accepted/In press - Dec 18 2015

Keywords

Cervical cancer
Early detection
Recurrence
Squamous cell carcinoma antigen

ASJC Scopus subject areas

Obstetrics and Gynaecology
Oncology

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title = "Squamous cell carcinoma antigen (SCC-Ag) during follow-up of cervical cancer patients: Role in the early diagnosis of recurrence",

abstract = "Objective: The aim of this study was to assess the potential benefit of routine squamous cell carcinoma antigen (SCC-Ag) assessment during follow-up of patients after treatment for early cervical cancer with regard to early diagnosis of cancer recurrence before clinical signs and symptoms occur. Methods: All clinical, pathological, and serological data of patients referred to the Department of Gynecologic Oncology between July 1999 and June 2014, were retrospectively collected and analyzed. The SCC-Ag levels of 197 patients with diagnosis of stage I or II cervical squamous carcinoma, were performed. Results: In the univariate analysis, serum SCC-Ag was not significantly associated with grading (p = 0.85), LVSI (p = 0.95) and FIGO stage (p = 0.83) but it was significantly associated with recurrence of disease (p ",

keywords = "Cervical cancer, Early detection, Recurrence, Squamous cell carcinoma antigen",

author = "Michela Salvatici and Achilarre, {Maria T.} and Sandri, {Maria T.} and Sara Boveri and Zanagnolo Vanna and Fabio Landoni",

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T1 - Squamous cell carcinoma antigen (SCC-Ag) during follow-up of cervical cancer patients

T2 - Role in the early diagnosis of recurrence

AU - Salvatici, Michela

AU - Achilarre, Maria T.

AU - Sandri, Maria T.

AU - Boveri, Sara

AU - Vanna, Zanagnolo

AU - Landoni, Fabio

PY - 2015/12/18

Y1 - 2015/12/18

N2 - Objective: The aim of this study was to assess the potential benefit of routine squamous cell carcinoma antigen (SCC-Ag) assessment during follow-up of patients after treatment for early cervical cancer with regard to early diagnosis of cancer recurrence before clinical signs and symptoms occur. Methods: All clinical, pathological, and serological data of patients referred to the Department of Gynecologic Oncology between July 1999 and June 2014, were retrospectively collected and analyzed. The SCC-Ag levels of 197 patients with diagnosis of stage I or II cervical squamous carcinoma, were performed. Results: In the univariate analysis, serum SCC-Ag was not significantly associated with grading (p = 0.85), LVSI (p = 0.95) and FIGO stage (p = 0.83) but it was significantly associated with recurrence of disease (p

AB - Objective: The aim of this study was to assess the potential benefit of routine squamous cell carcinoma antigen (SCC-Ag) assessment during follow-up of patients after treatment for early cervical cancer with regard to early diagnosis of cancer recurrence before clinical signs and symptoms occur. Methods: All clinical, pathological, and serological data of patients referred to the Department of Gynecologic Oncology between July 1999 and June 2014, were retrospectively collected and analyzed. The SCC-Ag levels of 197 patients with diagnosis of stage I or II cervical squamous carcinoma, were performed. Results: In the univariate analysis, serum SCC-Ag was not significantly associated with grading (p = 0.85), LVSI (p = 0.95) and FIGO stage (p = 0.83) but it was significantly associated with recurrence of disease (p

KW - Cervical cancer

KW - Early detection

KW - Recurrence

KW - Squamous cell carcinoma antigen

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