Squamous cell carcinoma with prominent myxoid stroma

Mario P. Foschini, Ezio Fulcheri, Patrizia Baracchini, Claudio Ceccarelli, Christine M. Betts, Vincenzo Eusebi

Research output: Contribution to journalArticlepeer-review


Three cases of a squamous cell carcinoma with a prominent myxoid stroma are reported. One case in a 70-year-old woman had presented as a lump in the breast, the other two presented as polypoid lesions of the larynx and cervix uteri in a 65-year-old man and 61-year-old woman, respectively. The carcinomatous component was immersed in abundant extracellular mucosubstances. In addition to occasional squamous pearls, it displayed immunocytochemical evidence of high-weight keratin present in the neoplastic cells and, in one case, desmosomal attachment under electron microscopy. The extracellular mucosubstances proved to be similar to those seen in connective tissue. The differential diagnosis with histologically similar lesions has been taken into consideration, and it has been suggested that this newly described entity showing abundant myxoid stroma has to be distinguished from numerous benign and malignant myxoid soft tissue tumors.

Original languageEnglish
Pages (from-to)859-865
Number of pages7
JournalHuman Pathology
Issue number8
Publication statusPublished - 1990


  • breast
  • cervix uteri
  • larynx
  • myxoid stroma
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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