Squamous cell carcinomas of the lung and of the head and neck: New insights on molecular characterization

Valentina Polo, Giulia Pasello, Stefano Frega, Adolfo Favaretto, Haralabos Koussis, Pierfranco Conte, Laura Bonanno

Research output: Contribution to journalArticlepeer-review

Abstract

Squamous cell carcinomas of the lung and of the head and neck district share strong association with smoking habits and are characterized by smoke-related genetic alterations. Driver mutations have been identified in small percentage of lung squamous cell carcinoma. In parallel, squamous cell head and neck tumors are classified according to the HPV positivity, thus identifying two different clinical and molecular subgroups of disease. This review depicts different molecular portraits and potential clinical application in the field targeted therapy, immunotherapy and chemotherapy personalization.

Original languageEnglish
Pages (from-to)25050-25063
Number of pages14
JournalOncotarget
Volume7
Issue number18
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Head and head
  • HPV
  • Lung
  • Molecular characterization
  • Smoke
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology

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