Src family kinases are necessary for cell migration induced by extracellular HMGB1

Roberta Palumbo, Francesco De Marchis, Tobias Pusterla, Antonio Conti, Massimo Alessio, Marco E. Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

HMGB1 is a nuclear protein that signals tissue damage, as it is released by cells dying traumatically or secreted by activated innate immunity cells. Extracellular HMGB1 elicits the migration to the site of tissue damage of several cell types, including inflammatory cells and stem cells. The identity of the signaling pathways activated by extracellular HMGB1 is not known completely: We reported previously that ERK and NF-κB pathways are involved, and we report here that Src is also activated. The ablation of Src or inhibition with the kinase inhibitor PP2 blocks migration toward HMGB1. Src associates to and mediates the phosphorylation of FAK and the formation of focal adhesions.

Original languageEnglish
Pages (from-to)617-623
Number of pages7
JournalJournal of Leukocyte Biology
Volume86
Issue number3
DOIs
Publication statusPublished - Sep 1 2009

Keywords

  • Chemokines
  • DAMP
  • Danger signals
  • Stem cells
  • Tissue repair

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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