SREBF-2 polymorphism influences white matter microstructure in bipolar disorder

Sara Poletti, Veronica Aggio, Irene Bollettini, Andrea Falini, Cristina Colombo, Francesco Benedetti

Research output: Contribution to journalArticle

Abstract

The aim of the study is to investigate if gene polymorphisms in sterol regulatory element binding protein transcriptional factors SREBF-1 and SREBF-2, which regulate lipid and cholesterol metabolism, could affect white matter (WM) microstructure, the most recognized structural biomarker of bipolar disorder (BD). In a sample of 93 patients affected by BD, we investigated the effect of SREBF-1 rs11868035, and SREBF-2 rs1052717, on WM microstructure, using diffusion tensor imaging and tract-based spatial statistics. We observed increased radial diffusivity in the rs1052717 A/A genotype compared to A/G and G/G, and reduced fractional anisotropy (FA) in the rs1052717 A/A genotype compared to G carriers in cingulum, corpus callosum, superior and inferior longitudinal fasciculi, and anterior thalamic radiation. These results seem to suggest an involvement of SREBF-2 in the integrity of white matter tracts in BD and therefore a possible role of SREBP pathway in CNS myelination processes.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume257
DOIs
Publication statusPublished - Nov 30 2016

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Keywords

  • Bipolar disorder
  • Cholesterol
  • Myelination
  • Sterol regulatory element binding protein
  • White matter

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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