Stability of bortezomib reconstituted under clinical use conditions in original vials and polypropylene syringes at 4°C and room temperature

Daniela Carati, Carla Masini, Martina Minguzzi, Benedetta Petocchi, Cristiana Romanazzi, Cristina Rondoni, Elisa Sangiorgi, Stella Sferra, Sara Simonetta, Alessandra Stancari, Federica Locchi, Alessandra Zanardi

Research output: Contribution to journalArticle

Abstract

Purpose Bortezomib (Velcade) is an antineoplastic drug widely used in the treatment of multiple myeloma. According to the manufacturer, once reconstituted, bortezomib is only stable for 8 h at 25°C. The aim of this study was to evaluate the stability of reconstituted bortezomib stored in original vials and syringes at 4°C and 28°C, for up to 10 days. Methods Samples were prepared by dissolving 3.5 mg of bortezomib powder in 3.5 ml of physi-ological saline (final concentration 1 mg/ml) under routine clinical conditions. Samples were stored in vials or syringes at 4°C and 28°C with photopro-tection, and drug stability was analysed by high performance liquid chromatography. results Bortezomib was stable in both original vials and syringes for up to 10 days at 4°C with photoprotection. Furthermore, it was stable for up to 8 days at 28°C in original vials with photopro-tection. conclusions Our results showed an extended stability of bortezomib prepared under routine clinical conditions and stored at 4°C, which could make an important contribution towards reducing drug waste and, consequently, improving cost efficiency.

Original languageEnglish
Pages (from-to)428-431
Number of pages4
JournalEuropean Journal of Hospital Pharmacy
Volume19
Issue number5
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Carati, D., Masini, C., Minguzzi, M., Petocchi, B., Romanazzi, C., Rondoni, C., Sangiorgi, E., Sferra, S., Simonetta, S., Stancari, A., Locchi, F., & Zanardi, A. (2012). Stability of bortezomib reconstituted under clinical use conditions in original vials and polypropylene syringes at 4°C and room temperature. European Journal of Hospital Pharmacy, 19(5), 428-431. https://doi.org/10.1136/ejhpharm-2011-000041