Stability of ifosfamide in solutions for multiday infusion by external pump

L. Leone, A. Comandone, C. Oliva, P. Bussi, F. Goffredo, S. Bretti, C. Bumma

Research output: Contribution to journalArticle

Abstract

The stability of ifosfamide in Ringer lactate buffer solution either alone or mixed with mesna at 37°C for a 7-day period was analyzed by HPLC. This study was performed to investigate the feasibility of continuous infusion of ifosfamide by a multiday pump in order to reduce the toxicity and to increase the production of active alkylating metabolites of the parent drug. The total decay of ifosfamide activity did not exceed 3.2% at day 7. We conclude that ifosfamide can be safely delivered in a 7-day infusion with no significant loss of activity.

Original languageEnglish
Pages (from-to)604-607
Number of pages4
JournalAnti-Cancer Drugs
Volume6
Issue number4
Publication statusPublished - 1995

Keywords

  • Ifosfamide
  • Infusion
  • Pump
  • Stability

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research
  • Oncology

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    Leone, L., Comandone, A., Oliva, C., Bussi, P., Goffredo, F., Bretti, S., & Bumma, C. (1995). Stability of ifosfamide in solutions for multiday infusion by external pump. Anti-Cancer Drugs, 6(4), 604-607.