Stability of L-[S-methyl-11C]methionine solutions

A. Bogni, E. Bombardieri, R. Iwata, L. Cadini, C. Pascali

Research output: Contribution to journalArticlepeer-review


For clinical PET studies L-[S-methyl-11C]methionine (11C]MET) solutions have been prepared in both high doses and specific activities (up to 48.1 GBq and 370 GBq/μmol, respectively) with high radiochemical purity (>99%). The stability of these preparations was investigated by HPLC to ensure the radiopharmaceutical efficacy during the usable shelf life. Under our routine conditions the observed radiochemical purity loss never exceeded 3.5% one hour after EOS. The decomposition rate was affected by total activity and chemical composition of the solutions.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Issue number2
Publication statusPublished - May 1 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Inorganic Chemistry
  • Nuclear Energy and Engineering


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