Stacked autoencoders as new models for an accurate Alzheimer's disease classification support using resting-state EEG and MRI measurements

Raffaele Ferri, Claudio Babiloni, Vania Karami, Antonio Ivano Triggiani, Filippo Carducci, Giuseppe Noce, Roberta Lizio, Maria T. Pascarelli, Andrea Soricelli, Francesco Amenta, Alessandro Bozzao, Andrea Romano, Franco Giubilei, Claudio Del Percio, Fabrizio Stocchi, Giovanni B. Frisoni, Flavio Nobili, Luca Patanè, Paolo Arena

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This retrospective and exploratory study tested the accuracy of artificial neural networks (ANNs) at detecting Alzheimer's disease patients with dementia (ADD) based on input variables extracted from resting-state electroencephalogram (rsEEG), structural magnetic resonance imaging (sMRI) or both. Methods: For the classification exercise, the ANNs had two architectures that included stacked (autoencoding) hidden layers recreating input data in the output. The classification was based on LORETA source estimates from rsEEG activity recorded with 10–20 montage system (19 electrodes) and standard sMRI variables in 89 ADD and 45 healthy control participants taken from a national database. Results: The ANN with stacked autoencoders and a deep leaning model representing both ADD and control participants showed classification accuracies in discriminating them of 80%, 85%, and 89% using rsEEG, sMRI, and rsEEG + sMRI features, respectively. The two ANNs with stacked autoencoders and a deep leaning model specialized for either ADD or control participants showed classification accuracies of 77%, 83%, and 86% using the same input features. Conclusions: The two architectures of ANNs using stacked (autoencoding) hidden layers consistently reached moderate to high accuracy in the discrimination between ADD and healthy control participants as a function of the rsEEG and sMRI features employed. Significance: The present results encourage future multi-centric, prospective and longitudinal cross-validation studies using high resolution EEG techniques and harmonized clinical procedures towards clinical applications of the present ANNs.

Original languageEnglish
JournalClinical Neurophysiology
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Alzheimer's Disease (AD)
  • Low-resolution brain electromagnetic tomography (LORETA)
  • Resting State Electroencephalography (rsEEG)
  • Stacked Artificial Neural Networks (ANNs) with Autoencoders

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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