TY - JOUR
T1 - Stage dependent destructuration of neuro-endocrine-immune system components in lung cancer patients
AU - Mazzoccoli, Gianluigi
AU - Fontana, Andrea
AU - Copetti, Massimiliano
AU - Pellegrini, Fabio
AU - Piepoli, Ada
AU - Muscarella, Lucia Anna
AU - Pazienza, Valerio
AU - Giuliani, Francesco
AU - Tarquini, Roberto
PY - 2011/2
Y1 - 2011/2
N2 - Background: Close relationships among the nervous, endocrine and immune system components maintain body homeostasis. Alteration of time-related prophile of variation of system components and loss of integrated function may favour the developing of cancer and may be aggravated in the presence of neoplastic disease. The aim of our study was to evaluate the prophiles of time-related variation of neuro-endocrine-immune system components in lung cancer patients. Methods: Peripheral blood samples were collected at intervals of 4 hours for 24 hours from 11 healthy subjects (age range 35-53 years, mean age ± s.e. 43.6 ± 1.7) and nine patients suffering from nonsmall cell lung cancer (age range 43-63 years, mean age ± s.e. 51.0 ± 2.4). In each blood sample, lymphocyte subpopulations (CD3, CD4, CD8, HLA-DR, CD16, CD20, CD25, γδTcR) were analyzed and melatonin, cortisol, TRH, TSH, free thyroxine, GH, IGF1 and interleukin IL2 on serum were measured. Results: In our I-II stage lung cancer patients CD8+ lymphocytes (P= 0.01), and in particular the T suppressor subset (P
AB - Background: Close relationships among the nervous, endocrine and immune system components maintain body homeostasis. Alteration of time-related prophile of variation of system components and loss of integrated function may favour the developing of cancer and may be aggravated in the presence of neoplastic disease. The aim of our study was to evaluate the prophiles of time-related variation of neuro-endocrine-immune system components in lung cancer patients. Methods: Peripheral blood samples were collected at intervals of 4 hours for 24 hours from 11 healthy subjects (age range 35-53 years, mean age ± s.e. 43.6 ± 1.7) and nine patients suffering from nonsmall cell lung cancer (age range 43-63 years, mean age ± s.e. 51.0 ± 2.4). In each blood sample, lymphocyte subpopulations (CD3, CD4, CD8, HLA-DR, CD16, CD20, CD25, γδTcR) were analyzed and melatonin, cortisol, TRH, TSH, free thyroxine, GH, IGF1 and interleukin IL2 on serum were measured. Results: In our I-II stage lung cancer patients CD8+ lymphocytes (P= 0.01), and in particular the T suppressor subset (P
KW - Destructuration
KW - Lung cancer
KW - Neuro-endocrine-immune system
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U2 - 10.1016/j.biopha.2010.12.006
DO - 10.1016/j.biopha.2010.12.006
M3 - Article
C2 - 21232906
AN - SCOPUS:79951675093
VL - 65
SP - 69
EP - 76
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
SN - 0753-3322
IS - 1
ER -