Stage dependent destructuration of neuro-endocrine-immune system components in lung cancer patients

Gianluigi Mazzoccoli, Andrea Fontana, Massimiliano Copetti, Fabio Pellegrini, Ada Piepoli, Lucia Anna Muscarella, Valerio Pazienza, Francesco Giuliani, Roberto Tarquini

Research output: Contribution to journalArticle


Background: Close relationships among the nervous, endocrine and immune system components maintain body homeostasis. Alteration of time-related prophile of variation of system components and loss of integrated function may favour the developing of cancer and may be aggravated in the presence of neoplastic disease. The aim of our study was to evaluate the prophiles of time-related variation of neuro-endocrine-immune system components in lung cancer patients. Methods: Peripheral blood samples were collected at intervals of 4 hours for 24 hours from 11 healthy subjects (age range 35-53 years, mean age ± s.e. 43.6 ± 1.7) and nine patients suffering from nonsmall cell lung cancer (age range 43-63 years, mean age ± s.e. 51.0 ± 2.4). In each blood sample, lymphocyte subpopulations (CD3, CD4, CD8, HLA-DR, CD16, CD20, CD25, γδTcR) were analyzed and melatonin, cortisol, TRH, TSH, free thyroxine, GH, IGF1 and interleukin IL2 on serum were measured. Results: In our I-II stage lung cancer patients CD8+ lymphocytes (P= 0.01), and in particular the T suppressor subset (P

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalBiomedicine and Pharmacotherapy
Issue number1
Publication statusPublished - Feb 2011



  • Destructuration
  • Lung cancer
  • Neuro-endocrine-immune system

ASJC Scopus subject areas

  • Pharmacology

Cite this