Stage-related differences of mitotic and apoptotic indices, and bcl-2 protein expression in diffusely growing non-Hodgkin's lymphomas

Donatella Spina, Lorenzo Leoncini, Tiziana Megha, Maria T. Del Vecchio, Chiara Minacci, Simonetta Poggi, Stefano Pileri, Piero Tosi, Rainer Kraft, Jean A. Laissue, Hans Cottier

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Abstract

The present study examined whether growth characteristics of diffusely growing non-Hodgkin's lymphomas (NHL) may differ as a function of stage. Among 105 NHL of various types and sub-types (REAL [Revised European-American Lymphoma] classification), localized (Ann Arbor pathologic stages I + II) lymphomas exhibited clearly higher indices for mitotic activity, apoptosis and cell turnover, as well as a significantly lower percentage of cells containing immunohistochemically detectable bcl-2 protein, than disseminated (stages III + IV) NHL. A similar pattern emerged when high-grade (Kiel classification) lymphomas only were evaluated. Low-grade NHL showed analogous, but less marked, stage-dependent characteristics, with the exception of median percentages of bcl-2+ cells, which remained comparable in all stages. Our findings are consistent with the notion that dissemination of diffusely growing NHL is usually associated with reduced cell turnover and, in high-grade lymphomas, with the generation of longer-lived cells.

Original languageEnglish
Pages (from-to)436-440
Number of pages5
JournalInternational Journal of Cancer
Volume68
Issue number4
DOIs
Publication statusPublished - 1996

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Mitotic Index
Non-Hodgkin's Lymphoma
Proteins
Lymphoma
Apoptosis
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Stage-related differences of mitotic and apoptotic indices, and bcl-2 protein expression in diffusely growing non-Hodgkin's lymphomas. / Spina, Donatella; Leoncini, Lorenzo; Megha, Tiziana; Del Vecchio, Maria T.; Minacci, Chiara; Poggi, Simonetta; Pileri, Stefano; Tosi, Piero; Kraft, Rainer; Laissue, Jean A.; Cottier, Hans.

In: International Journal of Cancer, Vol. 68, No. 4, 1996, p. 436-440.

Research output: Contribution to journalArticle

Spina, Donatella ; Leoncini, Lorenzo ; Megha, Tiziana ; Del Vecchio, Maria T. ; Minacci, Chiara ; Poggi, Simonetta ; Pileri, Stefano ; Tosi, Piero ; Kraft, Rainer ; Laissue, Jean A. ; Cottier, Hans. / Stage-related differences of mitotic and apoptotic indices, and bcl-2 protein expression in diffusely growing non-Hodgkin's lymphomas. In: International Journal of Cancer. 1996 ; Vol. 68, No. 4. pp. 436-440.
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AU - Poggi, Simonetta

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