Cancer prognostic systems are essential for designing and conducting clinical trials, assessing the impact of new technologies, and comparing different patient populations. The development of a cancer prognostic system should be considered a dynamic process, as the system needs to be periodically updated when new prognostic factors become available. It is important that changes to cancer prognostic systems follow an appropriate methodology. A prognostic system for patients with HCC needs to combine tumor extent and residual liver function. At the moment, the CLIP score, which is easy to calculate and based on objective parameters, has been validated prospectively and in different populations represents the most useful prognostic system for HCC.
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