Staging of chronic lymphocytic leukemia

M. Baccarani, M. Cavo, M. Gobbi, F. Lauria, S. Tura

Research output: Contribution to journalArticle

Abstract

One-hundred and eighty-eight patients with chronic lymphocytic leukemia were analyzed for prognosis based on Rai's staging system. It was found that stages I and II were not homogeneous as to prognosis. Stage II patients presenting with isolated splenomegaly had a long survival and were pooled with stage 0 patients (low risk group, 30% of cases, relative death rate 0.24, median survival > 10 yr). Stages I and II patients with a lymphocyte count higher than 40 x 109/liter had a short survival and were pooled with stages III and IV patients (high risk group, 39% of cases, relative death rate 1.91, median survival 3.3 yr). Stages I and II patients with a lymphocyte count lower than 40 x 109/liter made up an intermediate or standard risk group (31% of cases, relative death rate 1.00, median survival 6.2 yr). This modified staging system applied successfully to both old and young patients (more and less than 60 yr old, respectively).

Original languageEnglish
Pages (from-to)1191-1196
Number of pages6
JournalBlood
Volume59
Issue number6
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Hematology

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    Baccarani, M., Cavo, M., Gobbi, M., Lauria, F., & Tura, S. (1982). Staging of chronic lymphocytic leukemia. Blood, 59(6), 1191-1196.