Staging of colon cancer: Whole-body MRI vs. whole-body PET-CT - Initial clinical experience

Ettore Squillaci, Guglielmo Manenti, Stefano Mancino, Carmelo Cicciò, Ferdinando Calabria, Roberta Danieli, Orazio Schillaci, Giovanni Simonetti

Research output: Contribution to journalArticle

Abstract

Background: To assess the accuracy of whole-body MR imaging (WB-MRI) in comparison with whole-body [18F]-2-fluoro-2-deoxy-d-glucose (FDG) PET-CT in staging patients with diagnosed colorectal carcinoma (CRC). Methods: Twenty consecutive patients with previously diagnosed CRC underwent WB-MRI (3T) and PET-CT for staging of lymph node (N) and distant metastases (M). Evaluation was done according to the American Joint Committee on Cancer Staging Criteria. MR images were evaluated by two radiologists while PET-CT images by one radiologist and one nuclear medicine physician. Histology and/or a clinical follow-up of 3-6 months served as standard of reference. Results: Lymph node involvement was determined in 10/20 cases as N-positive in WB-MRI and in 15/20 in PET-CT. M-stage was evaluated for liver metastases (27 lesions in 15 patients with WB-MRI, 23/15 patients with PET-CT), lung (19/5 patients with WB-MRI, 25/7 patients with PET-CT), and bone (9/3 patients with WB-MRI, 9/3 patients with PET-CT). Two patients showed peritoneal implants and three patients demonstrated local recurrence at the surgery site on both modalities. No brain metastases were found. Conclusions: WB-MRI is a feasible method for examining colon cancer patients but cannot displace the present role of PET-CT.

Original languageEnglish
Pages (from-to)676-688
Number of pages13
JournalAbdominal Imaging
Volume33
Issue number6
DOIs
Publication statusPublished - Nov 2008

    Fingerprint

Keywords

  • Colorectal carcinoma (CRC)
  • Colorectal carcinoma metastasis
  • Colorectal carcinoma staging
  • Positron emission tomography (PET) computed tomography (CT)
  • Whole-body MRI (WB-MRI)

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging
  • Urology
  • Radiological and Ultrasound Technology

Cite this

Squillaci, E., Manenti, G., Mancino, S., Cicciò, C., Calabria, F., Danieli, R., Schillaci, O., & Simonetti, G. (2008). Staging of colon cancer: Whole-body MRI vs. whole-body PET-CT - Initial clinical experience. Abdominal Imaging, 33(6), 676-688. https://doi.org/10.1007/s00261-007-9347-5