Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy

Annalisa Macera, Chiara Lario, Massimo Petracchini, Teresa Gallo, Daniele Regge, Irene Floriani, Dario Ribero, Lorenzo Capussotti, Stefano Cirillo

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To compare the diagnostic accuracy and sensitivity of Gd-EOB-DTPA MRI and diffusion-weighted (DWI) imaging alone and in combination for detecting colorectal liver metastases in patients who had undergone preoperative chemotherapy. Methods: Thirty-two consecutive patients with a total of 166 liver lesions were retrospectively enrolled. Of the lesions, 144 (86.8 %) were metastatic at pathology. Three image sets (1, Gd-EOB-DTPA; 2, DWI; 3, combined Gd-EOB-DTPA and DWI) were independently reviewed by two observers. Statistical analysis was performed on a per-lesion basis. Results: Evaluation of image set 1 correctly identified 127/166 lesions (accuracy 76.5 %; 95 % CI 69.3-82.7) and 106/144 metastases (sensitivity 73.6 %, 95 % CI 65.6-80.6). Evaluation of image set 2 correctly identified 108/166 (accuracy 65.1 %, 95 % CI 57.3-72.3) and 87/144 metastases (sensitivity of 60.4 %, 95 % CI 51.9-68.5). Evaluation of image set 3 correctly identified 148/166 (accuracy 89.2 %, 95 % CI 83.4-93.4) and 131/144 metastases (sensitivity 91 %, 95 % CI 85.1-95.1). Differences were statistically significant (P <0.001). Notably, similar results were obtained analysing only small lesions (

Original languageEnglish
Pages (from-to)739-747
Number of pages9
JournalEuropean Radiology
Volume23
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Chemotreated patients
  • Colorectal liver metastases
  • DWI
  • Gd-EOB-DTPA enhanced MRI
  • Small lesions

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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