Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy

Annalisa Macera, Chiara Lario, Massimo Petracchini, Teresa Gallo, Daniele Regge, Irene Floriani, Dario Ribero, Lorenzo Capussotti, Stefano Cirillo

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objectives: To compare the diagnostic accuracy and sensitivity of Gd-EOB-DTPA MRI and diffusion-weighted (DWI) imaging alone and in combination for detecting colorectal liver metastases in patients who had undergone preoperative chemotherapy. Methods: Thirty-two consecutive patients with a total of 166 liver lesions were retrospectively enrolled. Of the lesions, 144 (86.8 %) were metastatic at pathology. Three image sets (1, Gd-EOB-DTPA; 2, DWI; 3, combined Gd-EOB-DTPA and DWI) were independently reviewed by two observers. Statistical analysis was performed on a per-lesion basis. Results: Evaluation of image set 1 correctly identified 127/166 lesions (accuracy 76.5 %; 95 % CI 69.3-82.7) and 106/144 metastases (sensitivity 73.6 %, 95 % CI 65.6-80.6). Evaluation of image set 2 correctly identified 108/166 (accuracy 65.1 %, 95 % CI 57.3-72.3) and 87/144 metastases (sensitivity of 60.4 %, 95 % CI 51.9-68.5). Evaluation of image set 3 correctly identified 148/166 (accuracy 89.2 %, 95 % CI 83.4-93.4) and 131/144 metastases (sensitivity 91 %, 95 % CI 85.1-95.1). Differences were statistically significant (P <0.001). Notably, similar results were obtained analysing only small lesions (

Original languageEnglish
Pages (from-to)739-747
Number of pages9
JournalEuropean Radiology
Volume23
Issue number3
DOIs
Publication statusPublished - 2013

Fingerprint

Neoplasm Metastasis
Drug Therapy
Liver
Diffusion Magnetic Resonance Imaging
Pathology
gadolinium ethoxybenzyl DTPA

Keywords

  • Chemotreated patients
  • Colorectal liver metastases
  • DWI
  • Gd-EOB-DTPA enhanced MRI
  • Small lesions

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy. / Macera, Annalisa; Lario, Chiara; Petracchini, Massimo; Gallo, Teresa; Regge, Daniele; Floriani, Irene; Ribero, Dario; Capussotti, Lorenzo; Cirillo, Stefano.

In: European Radiology, Vol. 23, No. 3, 2013, p. 739-747.

Research output: Contribution to journalArticle

Macera, Annalisa ; Lario, Chiara ; Petracchini, Massimo ; Gallo, Teresa ; Regge, Daniele ; Floriani, Irene ; Ribero, Dario ; Capussotti, Lorenzo ; Cirillo, Stefano. / Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy. In: European Radiology. 2013 ; Vol. 23, No. 3. pp. 739-747.
@article{2cafe1e1cce04a9890882725d10956ca,
title = "Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy",
abstract = "Objectives: To compare the diagnostic accuracy and sensitivity of Gd-EOB-DTPA MRI and diffusion-weighted (DWI) imaging alone and in combination for detecting colorectal liver metastases in patients who had undergone preoperative chemotherapy. Methods: Thirty-two consecutive patients with a total of 166 liver lesions were retrospectively enrolled. Of the lesions, 144 (86.8 {\%}) were metastatic at pathology. Three image sets (1, Gd-EOB-DTPA; 2, DWI; 3, combined Gd-EOB-DTPA and DWI) were independently reviewed by two observers. Statistical analysis was performed on a per-lesion basis. Results: Evaluation of image set 1 correctly identified 127/166 lesions (accuracy 76.5 {\%}; 95 {\%} CI 69.3-82.7) and 106/144 metastases (sensitivity 73.6 {\%}, 95 {\%} CI 65.6-80.6). Evaluation of image set 2 correctly identified 108/166 (accuracy 65.1 {\%}, 95 {\%} CI 57.3-72.3) and 87/144 metastases (sensitivity of 60.4 {\%}, 95 {\%} CI 51.9-68.5). Evaluation of image set 3 correctly identified 148/166 (accuracy 89.2 {\%}, 95 {\%} CI 83.4-93.4) and 131/144 metastases (sensitivity 91 {\%}, 95 {\%} CI 85.1-95.1). Differences were statistically significant (P <0.001). Notably, similar results were obtained analysing only small lesions (",
keywords = "Chemotreated patients, Colorectal liver metastases, DWI, Gd-EOB-DTPA enhanced MRI, Small lesions",
author = "Annalisa Macera and Chiara Lario and Massimo Petracchini and Teresa Gallo and Daniele Regge and Irene Floriani and Dario Ribero and Lorenzo Capussotti and Stefano Cirillo",
year = "2013",
doi = "10.1007/s00330-012-2658-0",
language = "English",
volume = "23",
pages = "739--747",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy

AU - Macera, Annalisa

AU - Lario, Chiara

AU - Petracchini, Massimo

AU - Gallo, Teresa

AU - Regge, Daniele

AU - Floriani, Irene

AU - Ribero, Dario

AU - Capussotti, Lorenzo

AU - Cirillo, Stefano

PY - 2013

Y1 - 2013

N2 - Objectives: To compare the diagnostic accuracy and sensitivity of Gd-EOB-DTPA MRI and diffusion-weighted (DWI) imaging alone and in combination for detecting colorectal liver metastases in patients who had undergone preoperative chemotherapy. Methods: Thirty-two consecutive patients with a total of 166 liver lesions were retrospectively enrolled. Of the lesions, 144 (86.8 %) were metastatic at pathology. Three image sets (1, Gd-EOB-DTPA; 2, DWI; 3, combined Gd-EOB-DTPA and DWI) were independently reviewed by two observers. Statistical analysis was performed on a per-lesion basis. Results: Evaluation of image set 1 correctly identified 127/166 lesions (accuracy 76.5 %; 95 % CI 69.3-82.7) and 106/144 metastases (sensitivity 73.6 %, 95 % CI 65.6-80.6). Evaluation of image set 2 correctly identified 108/166 (accuracy 65.1 %, 95 % CI 57.3-72.3) and 87/144 metastases (sensitivity of 60.4 %, 95 % CI 51.9-68.5). Evaluation of image set 3 correctly identified 148/166 (accuracy 89.2 %, 95 % CI 83.4-93.4) and 131/144 metastases (sensitivity 91 %, 95 % CI 85.1-95.1). Differences were statistically significant (P <0.001). Notably, similar results were obtained analysing only small lesions (

AB - Objectives: To compare the diagnostic accuracy and sensitivity of Gd-EOB-DTPA MRI and diffusion-weighted (DWI) imaging alone and in combination for detecting colorectal liver metastases in patients who had undergone preoperative chemotherapy. Methods: Thirty-two consecutive patients with a total of 166 liver lesions were retrospectively enrolled. Of the lesions, 144 (86.8 %) were metastatic at pathology. Three image sets (1, Gd-EOB-DTPA; 2, DWI; 3, combined Gd-EOB-DTPA and DWI) were independently reviewed by two observers. Statistical analysis was performed on a per-lesion basis. Results: Evaluation of image set 1 correctly identified 127/166 lesions (accuracy 76.5 %; 95 % CI 69.3-82.7) and 106/144 metastases (sensitivity 73.6 %, 95 % CI 65.6-80.6). Evaluation of image set 2 correctly identified 108/166 (accuracy 65.1 %, 95 % CI 57.3-72.3) and 87/144 metastases (sensitivity of 60.4 %, 95 % CI 51.9-68.5). Evaluation of image set 3 correctly identified 148/166 (accuracy 89.2 %, 95 % CI 83.4-93.4) and 131/144 metastases (sensitivity 91 %, 95 % CI 85.1-95.1). Differences were statistically significant (P <0.001). Notably, similar results were obtained analysing only small lesions (

KW - Chemotreated patients

KW - Colorectal liver metastases

KW - DWI

KW - Gd-EOB-DTPA enhanced MRI

KW - Small lesions

UR - http://www.scopus.com/inward/record.url?scp=84878620744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878620744&partnerID=8YFLogxK

U2 - 10.1007/s00330-012-2658-0

DO - 10.1007/s00330-012-2658-0

M3 - Article

C2 - 22976920

AN - SCOPUS:84878620744

VL - 23

SP - 739

EP - 747

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 3

ER -