Standard Deviation of normal interbeat intervals as a risk marker in patients with left ventricular systolic dysfunction: A meta-analysis

Marcos R. de Sousa, Marco P T Barbosa, Federico Lombardi, Antonio L P Ribeiro

Research output: Contribution to journalArticlepeer-review

Abstract

Our aim was to evaluate the Standard Deviation of Normal-Normal (SDNN) interbeat interval as a risk marker in left ventricular systolic dysfunction (LVSD) patients through a meta-analysis. We searched PubMed for studies that evaluated SDNN as a predictor of all-cause-death, cardiac death, transplantation, and progressive clinical deterioration using a search strategy validated for MEDLINE. Mean values and SD for SDNN in sixteen studies included were 115 ± 48 ms in survivors versus 87 ± 40 ms in non-survivors, resulting in a statistically significant standardized mean difference (0.594, 95%CI 0.385 to 0.803). In conclusion, SDNN may be a useful prognostic marker in LVSD. Additional studies must evaluate if SDNN may be used to subsidize therapeutic decisions.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalInternational Journal of Cardiology
Volume141
Issue number3
DOIs
Publication statusPublished - Jun 11 2010

Keywords

  • Heart failure
  • Heart rate variability
  • Left
  • Prognosis
  • Ventricular Dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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