Background: Recombinant human interleukin-2 (IL-2) has a well-documented anti-tumor activity against RCC and has demonstrated a synergistic anti-tumor activity between doxorubicin and IL-2, thus providing better survival. This study investigated the toxicity and efficacy of the association between IL-2 and interferon-α, and the immuno-chemoterapeutic association with IL-2 and 4-Epirubicin. Patients and methods: Patients with histologic evidence of metastatic or advanced RCC were randomized to receive either IL-2 + IFN-α (Arm A) or IL-2 + 4-Epi (Arm B). Arm A patients received IFN-α subcutaneously at doses of 3 million UI on days 1,3 and 5 for 6 weeks. Arm B patients received 4-EPI at doses of 25 mg/m2 on days 1, 8, 15, 22, 29 and 36. Treatment cycles were repeated at 10 week intervals. Results: Of 38 evaluable patients, we observed 2 complete responses, 2 partial responses, 1 minimal response, 1 mixed response, 21 stationary disease and 11 disease progressions. There was no significant difference in overall survival between the two groups. However in arm B, the median overall survival for responding patients was better than that of patients who experienced a disease progression. Performance status was the only predictive prognostic factor. Conclusions: Our analysis confirms the low response rate associated with IL-2 treatments but seems to indicate a role of anthracycline in improving the survival of responding patients with an acceptable toxicity.
|Number of pages||6|
|Issue number||3 B|
|Publication status||Published - May 1998|
- Metastatic renal cell carcinoma
ASJC Scopus subject areas
- Cancer Research