Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAE-Europe consensus review

L. Nobili, A. de Weerd, G. Rubboli, S. Beniczky, C. Derry, S. Eriksson, P. Halasz, B. Högl, J. Santamaria, R. Khatami, P. Ryvlin, J. Rémi, P. Tinuper, C. Bassetti, R. Manni, M. Koutroumanidis, L. Vignatelli

Research output: Contribution to journalArticlepeer-review


Background and purpose: Some epilepsy syndromes (sleep-related epilepsies, SREs) have a strong link with sleep. Comorbid sleep disorders are common in patients with SRE and can exert a negative impact on seizure control and quality of life. Our purpose was to define the standard procedures for the diagnostic pathway of patients with possible SRE (scenario 1) and the general management of patients with SRE and comorbidity with sleep disorders (scenario 2). Methods: The project was conducted under the auspices of the European Academy of Neurology, the European Sleep Research Society and the International League Against Epilepsy Europe. The framework entailed the following phases: conception of the clinical scenarios; literature review; statements regarding the standard procedures. For the literature search a stepwise approach starting from systematic reviews to primary studies was applied. Published studies were identified from the National Library of Medicine’s MEDLINE database and Cochrane Library. Results: Scenario 1: Despite a low quality of evidence, recommendations on anamnestic evaluation and tools for capturing the event at home or in the laboratory are provided for specific SREs. Scenario 2: Early diagnosis and treatment of sleep disorders (especially respiratory disorders) in patients with SRE are likely to be beneficial for seizure control. Conclusions: Definitive procedures for evaluating patients with SRE are lacking. Advice is provided that could be of help for standardizing and improving the diagnostic approach of specific SREs. The importance of identifying and treating specific sleep disorders for the management and outcome of patients with SRE is underlined.

Original languageEnglish
Pages (from-to)15-32
Number of pages18
JournalEuropean Journal of Neurology
Issue number1
Publication statusPublished - 2021


  • clinical and diagnostic investigations
  • clinical neurophysiology
  • electroencephalography (EEG)
  • epilepsy
  • guideline
  • insomnia
  • juvenile myoclonic epilepsy
  • neurological disorders
  • nocturnal seizures
  • panayiotopoulos syndrome
  • polysomnography
  • research methods
  • restless legs syndrome
  • rolandic epilepsy
  • seizure questionnaire
  • sleep-disordered breathing
  • sleep-related epilepsies

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAE-Europe consensus review'. Together they form a unique fingerprint.

Cite this