Standard treatment of acquired SAA in adult patients 18-40 years old with an HLA-identical sibling donor

M. Aljurf, H. Al-Zahrani, M. T. Van Lint, J. R. Passweg

Research output: Contribution to journalArticlepeer-review

Abstract

Matched related donor allo-SCT is the treatment of choice for patients with severe aplastic anemia (SAA) younger than 40 years of age. The standard conditioning regimen for such patients is cyclophosphamide with antithymocyte globulin. Unmanipulated BM is the best stem cell source for aplastic anemia patients going for SCT. Post-transplant GVHD prophylaxis with cyclosporine should be continued for 1 year. Early graft failure is rare but potentially life-threatening complication of SCT that can be managed with salvage SCT using more intense conditioning regimen.

Original languageEnglish
Pages (from-to)178-179
Number of pages2
JournalBone Marrow Transplantation
Volume48
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • aplastic anemia
  • identical sibling
  • transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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