Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity

Carlo Briguori, Antonio Colombo, Anna Violante, Pasquale Balestrieri, Fiore Manganelli, Pietro Paolo Elia, Bruno Golia, Stefano Lepore, Guido Riviezzo, Pierfranco Scarpato, Amelia Focaccio, Mariateresa Librera, Erminio Bonizzoni, Bruno Ricciardelli

Research output: Contribution to journalArticlepeer-review


Aims: Prophylactic administration of N-acetylcysteine (NAC) (600 mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. Methods and results: Two-hundred-twenty-four consecutive patients with chronic renal insufficiency (creatinine level ≥1.5 mg/dl and/or creatinine clearance 1) contrast dose, the event was significantly more frequent in the SD Group. Conclusions: Double dose of NAC seems to be more effective than the standard dose in preventing CAN, especially with high volumes of non-ionic, low-osmolality contrast agent.

Original languageEnglish
Pages (from-to)206-211
Number of pages6
JournalEuropean Heart Journal
Issue number3
Publication statusPublished - Feb 2004


  • Complications
  • Contrast media
  • Kidney
  • Prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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