Aims: Prophylactic administration of N-acetylcysteine (NAC) (600 mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. Methods and results: Two-hundred-twenty-four consecutive patients with chronic renal insufficiency (creatinine level ≥1.5 mg/dl and/or creatinine clearance 1) contrast dose, the event was significantly more frequent in the SD Group. Conclusions: Double dose of NAC seems to be more effective than the standard dose in preventing CAN, especially with high volumes of non-ionic, low-osmolality contrast agent.
- Contrast media
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine