Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity

Carlo Briguori; Antonio Colombo; Anna Violante; Pasquale Balestrieri; Fiore Manganelli; Pietro Paolo Elia; Bruno Golia; Stefano Lepore; Guido Riviezzo; Pierfranco Scarpato; Amelia Focaccio; Mariateresa Librera; Erminio Bonizzoni; Bruno Ricciardelli

doi:10.1016/j.ehj.2003.11.016

Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity

Carlo Briguori, Antonio Colombo, Anna Violante, Pasquale Balestrieri, Fiore Manganelli, Pietro Paolo Elia, Bruno Golia, Stefano Lepore, Guido Riviezzo, Pierfranco Scarpato, Amelia Focaccio, Mariateresa Librera, Erminio Bonizzoni, Bruno Ricciardelli

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: Prophylactic administration of N-acetylcysteine (NAC) (600 mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. Methods and results: Two-hundred-twenty-four consecutive patients with chronic renal insufficiency (creatinine level ≥1.5 mg/dl and/or creatinine clearance 1) contrast dose, the event was significantly more frequent in the SD Group. Conclusions: Double dose of NAC seems to be more effective than the standard dose in preventing CAN, especially with high volumes of non-ionic, low-osmolality contrast agent.

Original language	English
Pages (from-to)	206-211
Number of pages	6
Journal	European Heart Journal
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.ehj.2003.11.016
Publication status	Published - Feb 2004

Keywords

Complications
Contrast media
Kidney
Prevention

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ehj.2003.11.016

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Briguori, C., Colombo, A., Violante, A., Balestrieri, P., Manganelli, F., Elia, P. P., Golia, B., Lepore, S., Riviezzo, G., Scarpato, P., Focaccio, A., Librera, M., Bonizzoni, E., & Ricciardelli, B. (2004). Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity. European Heart Journal, 25(3), 206-211. https://doi.org/10.1016/j.ehj.2003.11.016

Briguori, C, Colombo, A, Violante, A, Balestrieri, P, Manganelli, F, Elia, PP, Golia, B, Lepore, S, Riviezzo, G, Scarpato, P, Focaccio, A, Librera, M, Bonizzoni, E & Ricciardelli, B 2004, 'Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity', European Heart Journal, vol. 25, no. 3, pp. 206-211. https://doi.org/10.1016/j.ehj.2003.11.016

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title = "Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity",

abstract = "Aims: Prophylactic administration of N-acetylcysteine (NAC) (600 mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. Methods and results: Two-hundred-twenty-four consecutive patients with chronic renal insufficiency (creatinine level ≥1.5 mg/dl and/or creatinine clearance 1) contrast dose, the event was significantly more frequent in the SD Group. Conclusions: Double dose of NAC seems to be more effective than the standard dose in preventing CAN, especially with high volumes of non-ionic, low-osmolality contrast agent.",

keywords = "Complications, Contrast media, Kidney, Prevention",

author = "Carlo Briguori and Antonio Colombo and Anna Violante and Pasquale Balestrieri and Fiore Manganelli and Elia, {Pietro Paolo} and Bruno Golia and Stefano Lepore and Guido Riviezzo and Pierfranco Scarpato and Amelia Focaccio and Mariateresa Librera and Erminio Bonizzoni and Bruno Ricciardelli",

year = "2004",

month = feb,

doi = "10.1016/j.ehj.2003.11.016",

language = "English",

volume = "25",

pages = "206--211",

journal = "European Heart Journal",

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T1 - Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity

AU - Briguori, Carlo

AU - Colombo, Antonio

AU - Violante, Anna

AU - Balestrieri, Pasquale

AU - Manganelli, Fiore

AU - Elia, Pietro Paolo

AU - Golia, Bruno

AU - Lepore, Stefano

AU - Riviezzo, Guido

AU - Scarpato, Pierfranco

AU - Focaccio, Amelia

AU - Librera, Mariateresa

AU - Bonizzoni, Erminio

AU - Ricciardelli, Bruno

PY - 2004/2

Y1 - 2004/2

N2 - Aims: Prophylactic administration of N-acetylcysteine (NAC) (600 mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. Methods and results: Two-hundred-twenty-four consecutive patients with chronic renal insufficiency (creatinine level ≥1.5 mg/dl and/or creatinine clearance 1) contrast dose, the event was significantly more frequent in the SD Group. Conclusions: Double dose of NAC seems to be more effective than the standard dose in preventing CAN, especially with high volumes of non-ionic, low-osmolality contrast agent.

AB - Aims: Prophylactic administration of N-acetylcysteine (NAC) (600 mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. Methods and results: Two-hundred-twenty-four consecutive patients with chronic renal insufficiency (creatinine level ≥1.5 mg/dl and/or creatinine clearance 1) contrast dose, the event was significantly more frequent in the SD Group. Conclusions: Double dose of NAC seems to be more effective than the standard dose in preventing CAN, especially with high volumes of non-ionic, low-osmolality contrast agent.

KW - Complications

KW - Contrast media

KW - Kidney

KW - Prevention

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VL - 25

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JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 3

ER -

Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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