Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups

EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.

METHODS: Participants were consulted through a modified Delphi method. Three sequential rounds occurred over 12 months. Members were sent a written questionnaire containing items divided into two parts. Items were identified and formulated based on a scoping review. The first part of the questionnaire referred to synovial biopsies in clinical practice including five subsections, and the second part to translational research with six subsections. Every participant was asked to score each item on a 5-point Likert scale. Items with a median score above 3.5 and a ≥ 70% agreement were selected for the next round. The last round was conducted orally at EULAR in June 2017.

RESULTS: Twenty-seven participants from 19 centers were contacted by email. Twenty participants from 17 centers answered. Response rates for next rounds were 100%. For the first part relating to clinical practice, 20/44 items (45.5%) were selected. For the second part relating to translational research, 18/43 items (41.9%) were selected for the final set.

CONCLUSIONS: We herein propose a consensual set of analysis items to be used for synovial biopsies conducted in clinical practice and translational research.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalArthritis Research and Therapy
Volume20
Issue number1
DOIs
Publication statusPublished - Dec 3 2018

Fingerprint

Translational Medical Research
Synovitis
Rheumatic Diseases
Biopsy
Surveys and Questionnaires

Keywords

  • Standardisation
  • Synovial biopsy
  • Synovial tissue analysis
  • Synovium

Cite this

Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups. / EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group.

In: Arthritis Research and Therapy, Vol. 20, No. 1, 03.12.2018, p. 1-7.

Research output: Contribution to journalArticle

EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group. / Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups. In: Arthritis Research and Therapy. 2018 ; Vol. 20, No. 1. pp. 1-7.
@article{8cdbbc8509294717b522c643f63d0f61,
title = "Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups",
abstract = "BACKGROUND: The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.METHODS: Participants were consulted through a modified Delphi method. Three sequential rounds occurred over 12 months. Members were sent a written questionnaire containing items divided into two parts. Items were identified and formulated based on a scoping review. The first part of the questionnaire referred to synovial biopsies in clinical practice including five subsections, and the second part to translational research with six subsections. Every participant was asked to score each item on a 5-point Likert scale. Items with a median score above 3.5 and a ≥ 70{\%} agreement were selected for the next round. The last round was conducted orally at EULAR in June 2017.RESULTS: Twenty-seven participants from 19 centers were contacted by email. Twenty participants from 17 centers answered. Response rates for next rounds were 100{\%}. For the first part relating to clinical practice, 20/44 items (45.5{\%}) were selected. For the second part relating to translational research, 18/43 items (41.9{\%}) were selected for the final set.CONCLUSIONS: We herein propose a consensual set of analysis items to be used for synovial biopsies conducted in clinical practice and translational research.",
keywords = "Standardisation, Synovial biopsy, Synovial tissue analysis, Synovium",
author = "{EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group} and Aur{\'e}lie Najm and {Le Goff}, Beno{\^i}t and Carl Orr and Rogier Thurlings and Ca{\~n}ete, {Juan D} and Frances Humby and Stefano Alivernini and Antonio Manzo and Just, {Soeren Andreas} and Rom{\~a}o, {Vasco C} and Veit Krenn and Ulf M{\"u}ller-Ladner and Olga Addimanda and Tas, {Sander W} and Maria Stoenoiu and {Meric de Bellefon}, Laurent and Patrick Durez and Vibeke Strand and Wechalekar, {Mihir D} and Fonseca, {Joao E} and Bernard Lauwerys and Ursula Fearon and Veale, {Douglas J}",
year = "2018",
month = "12",
day = "3",
doi = "10.1186/s13075-018-1762-1",
language = "English",
volume = "20",
pages = "1--7",
journal = "Arthritis Research and Therapy",
issn = "1478-6354",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups

AU - EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group

AU - Najm, Aurélie

AU - Le Goff, Benoît

AU - Orr, Carl

AU - Thurlings, Rogier

AU - Cañete, Juan D

AU - Humby, Frances

AU - Alivernini, Stefano

AU - Manzo, Antonio

AU - Just, Soeren Andreas

AU - Romão, Vasco C

AU - Krenn, Veit

AU - Müller-Ladner, Ulf

AU - Addimanda, Olga

AU - Tas, Sander W

AU - Stoenoiu, Maria

AU - Meric de Bellefon, Laurent

AU - Durez, Patrick

AU - Strand, Vibeke

AU - Wechalekar, Mihir D

AU - Fonseca, Joao E

AU - Lauwerys, Bernard

AU - Fearon, Ursula

AU - Veale, Douglas J

PY - 2018/12/3

Y1 - 2018/12/3

N2 - BACKGROUND: The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.METHODS: Participants were consulted through a modified Delphi method. Three sequential rounds occurred over 12 months. Members were sent a written questionnaire containing items divided into two parts. Items were identified and formulated based on a scoping review. The first part of the questionnaire referred to synovial biopsies in clinical practice including five subsections, and the second part to translational research with six subsections. Every participant was asked to score each item on a 5-point Likert scale. Items with a median score above 3.5 and a ≥ 70% agreement were selected for the next round. The last round was conducted orally at EULAR in June 2017.RESULTS: Twenty-seven participants from 19 centers were contacted by email. Twenty participants from 17 centers answered. Response rates for next rounds were 100%. For the first part relating to clinical practice, 20/44 items (45.5%) were selected. For the second part relating to translational research, 18/43 items (41.9%) were selected for the final set.CONCLUSIONS: We herein propose a consensual set of analysis items to be used for synovial biopsies conducted in clinical practice and translational research.

AB - BACKGROUND: The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.METHODS: Participants were consulted through a modified Delphi method. Three sequential rounds occurred over 12 months. Members were sent a written questionnaire containing items divided into two parts. Items were identified and formulated based on a scoping review. The first part of the questionnaire referred to synovial biopsies in clinical practice including five subsections, and the second part to translational research with six subsections. Every participant was asked to score each item on a 5-point Likert scale. Items with a median score above 3.5 and a ≥ 70% agreement were selected for the next round. The last round was conducted orally at EULAR in June 2017.RESULTS: Twenty-seven participants from 19 centers were contacted by email. Twenty participants from 17 centers answered. Response rates for next rounds were 100%. For the first part relating to clinical practice, 20/44 items (45.5%) were selected. For the second part relating to translational research, 18/43 items (41.9%) were selected for the final set.CONCLUSIONS: We herein propose a consensual set of analysis items to be used for synovial biopsies conducted in clinical practice and translational research.

KW - Standardisation

KW - Synovial biopsy

KW - Synovial tissue analysis

KW - Synovium

U2 - 10.1186/s13075-018-1762-1

DO - 10.1186/s13075-018-1762-1

M3 - Article

VL - 20

SP - 1

EP - 7

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

SN - 1478-6354

IS - 1

ER -