Standardization of autoimmune testing - Is it feasible?

Evanthia Monogioudi; Gustavo Martos; Dana Petronela Hutu; Heinz Schimmel; Pier Luigi Meroni; Joanna Sheldon; Ingrid Zegers

doi:10.1515/cclm-2017-1077

Standardization of autoimmune testing - Is it feasible?

Evanthia Monogioudi, Gustavo Martos, Dana Petronela Hutu, Heinz Schimmel, Pier Luigi Meroni, Joanna Sheldon, Ingrid Zegers

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Review article › peer-review

Abstract

Correct measurement of autoantibodies is essential for the diagnosis of autoimmune diseases. However, due to the variability of autoantibody results and the heterogeneity of testing, wrong diagnosis is a reality. For this and more reasons, harmonization of testing is of the outmost importance. In this review we have summarized the factors contributing to this variability. The ways with which the working group on harmonization of autoantibody testing of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has been trying to tackle the issue with the production and correct use of certified reference materials (CRMs), is discussed. Finally the advantages and the limitations of the use of CRMs are presented.

Original language	English
Pages (from-to)	1734-1742
Number of pages	9
Journal	Clinical Chemistry and Laboratory Medicine
Volume	56
Issue number	10
DOIs	https://doi.org/10.1515/cclm-2017-1077
Publication status	Published - Sep 25 2018

Keywords

autoimmune disease
certified reference materials
harmonization
standardization

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

Access to Document

10.1515/cclm-2017-1077

Cite this

@article{5b07c90c6b0042f8aacc5f33bf86ce34,

title = "Standardization of autoimmune testing - Is it feasible?",

abstract = "Correct measurement of autoantibodies is essential for the diagnosis of autoimmune diseases. However, due to the variability of autoantibody results and the heterogeneity of testing, wrong diagnosis is a reality. For this and more reasons, harmonization of testing is of the outmost importance. In this review we have summarized the factors contributing to this variability. The ways with which the working group on harmonization of autoantibody testing of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has been trying to tackle the issue with the production and correct use of certified reference materials (CRMs), is discussed. Finally the advantages and the limitations of the use of CRMs are presented.",

keywords = "autoimmune disease, certified reference materials, harmonization, standardization",

author = "Evanthia Monogioudi and Gustavo Martos and Hutu, {Dana Petronela} and Heinz Schimmel and Meroni, {Pier Luigi} and Joanna Sheldon and Ingrid Zegers",

year = "2018",

month = sep,

day = "25",

doi = "10.1515/cclm-2017-1077",

language = "English",

volume = "56",

pages = "1734--1742",

journal = "Clinical Chemistry and Laboratory Medicine",

issn = "1434-6621",