TY - JOUR
T1 - Standardization of autoimmune testing - Is it feasible?
AU - Monogioudi, Evanthia
AU - Martos, Gustavo
AU - Hutu, Dana Petronela
AU - Schimmel, Heinz
AU - Meroni, Pier Luigi
AU - Sheldon, Joanna
AU - Zegers, Ingrid
PY - 2018/9/25
Y1 - 2018/9/25
N2 - Correct measurement of autoantibodies is essential for the diagnosis of autoimmune diseases. However, due to the variability of autoantibody results and the heterogeneity of testing, wrong diagnosis is a reality. For this and more reasons, harmonization of testing is of the outmost importance. In this review we have summarized the factors contributing to this variability. The ways with which the working group on harmonization of autoantibody testing of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has been trying to tackle the issue with the production and correct use of certified reference materials (CRMs), is discussed. Finally the advantages and the limitations of the use of CRMs are presented.
AB - Correct measurement of autoantibodies is essential for the diagnosis of autoimmune diseases. However, due to the variability of autoantibody results and the heterogeneity of testing, wrong diagnosis is a reality. For this and more reasons, harmonization of testing is of the outmost importance. In this review we have summarized the factors contributing to this variability. The ways with which the working group on harmonization of autoantibody testing of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has been trying to tackle the issue with the production and correct use of certified reference materials (CRMs), is discussed. Finally the advantages and the limitations of the use of CRMs are presented.
KW - autoimmune disease
KW - certified reference materials
KW - harmonization
KW - standardization
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U2 - 10.1515/cclm-2017-1077
DO - 10.1515/cclm-2017-1077
M3 - Review article
AN - SCOPUS:85045933555
VL - 56
SP - 1734
EP - 1742
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
SN - 1434-6621
IS - 10
ER -