Standardization of the endogenous thrombin potential measurement: How to minimize the effect of residual platelets in stored plasma

Veena Chantarangkul, Marigrazia Clerici, Caterina Bressi, Armando Tripodi

Research output: Contribution to journalArticle

Abstract

Platelet contamination in stored plasma may affect coagulation assays, including the endogenous thrombin potential (ETP), which has been proposed for the investigation of hyper- and hypo-coagulability. The current recommendation of filtering plasma before freezing cannot be always met. This study provides evidence that filtering frozen plasma after thawing, prior to testing, may help to eliminate the unwanted effect of residual platelets on the ETP. This may have important implications in future studies, as the ETP could be determined with plasma that have been collected without precautions relating to platelet contamination, as is the case for plasmas collected in epidemiological studies.

Original languageEnglish
Pages (from-to)355-357
Number of pages3
JournalBritish Journal of Haematology
Volume124
Issue number3
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Hyper-coagulability
  • Hypo-coagulability
  • Standardization
  • Thrombosis

ASJC Scopus subject areas

  • Hematology

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