Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update

Kitty G. Snoek, Irwin K M Reiss, Anne Greenough, Irma Capolupo, Berndt Urlesberger, Lucas Wessel, Laurent Storme, Jan Deprest, Thomas Schaible, Arno Van Heijst, Dick Tibboel, K. Allegaert, A. Debeer, R. Keijzer, A. Benachi, P. Tissieres, F. Kipfmueller, T. Schaible, C. Breatnach, N. PatelE. Leva, F. Ciralli, P. Bagolan, A. Dotta, F. Morini, A. Di Pede, R. Emblem, K. Ertesvag, M. Migdal, A. Piotrowski, B. Frenckner, C. Mesas, D. Elorza, L. Martinez, H. Scharbatke, T. Cohen-Overbeek, A. J. Eggink, U. S. Kraemer, D. Tibboel, R. M H Wijnen, J. Deprest, P. De Coppi, S. Eaton, M. Davenport

Research output: Contribution to journalArticlepeer-review

Abstract

In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after a gestational age of 39 weeks in a high-volume tertiary center; (2) neuromuscular blocking agents to be avoided during initial treatment in the delivery room; (3) adapt treatment to reach a preductal saturation of between 80 and 95% and postductal saturation >70%; (4) target PaCO2 to be between 50 and 70 mm Hg; (5) conventional mechanical ventilation to be the optimal initial ventilation strategy, and (6) intravenous sildenafil to be considered in CDH patients with severe pulmonary hypertension. This article represents the current opinion of all consortium members in Europe for the optimal neonatal treatment of CDH.

Original languageEnglish
Pages (from-to)66-74
Number of pages9
JournalNeonatology
Volume110
Issue number1
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • Congenital diaphragmatic hernia
  • Consensus
  • Standardized treatment

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

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