Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update

Kitty G. Snoek, Irwin K M Reiss, A. Greenough, Irma Capolupo, Berndt Urlesberger, Lucas Wessel, Laurent Storme, Jan Deprest, Thomas Schaible, Arno van Heijst, Dick Tibboel, Karel Allegaert, Anne Debeer, R. Keijzer, Alexandra Benachi, P. Tissieres, F. Kipfmueller, T. Schaible, C. Breatnach, N. PatelErnesto Leva, Fabrizio Ciralli, Pietro Bagolan, Andrea Dotta, Francesco Morini, A. Di Pede, R. Emblem, K. Ertesvag, M. Migdal, A. Piotrowski, Bjorn P. Frenckner, C. Mesas, D. Elorza, Leopoldo Martínez, H. Scharbatke, T. Cohen-Overbeek, A. J. Eggink, Ulrike Kraemer, D. Tibboel, Rene Wijnen, J. Deprest, Paolo De Coppi, S. Eaton, M. Davenport

Research output: Contribution to journalArticle

Abstract

In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after a gestational age of 39 weeks in a high-volume tertiary center; (2) neuromuscular blocking agents to be avoided during initial treatment in the delivery room; (3) adapt treatment to reach a preductal saturation of between 80 and 95% and postductal saturation >70%; (4) target PaCO2 to be between 50 and 70 mm Hg; (5) conventional mechanical ventilation to be the optimal initial ventilation strategy, and (6) intravenous sildenafil to be considered in CDH patients with severe pulmonary hypertension. This article represents the current opinion of all consortium members in Europe for the optimal neonatal treatment of CDH.

Original languageEnglish
Pages (from-to)66-74
Number of pages9
JournalNeonatology
Volume110
Issue number1
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Delivery Rooms
Neuromuscular Blocking Agents
Clinical Protocols
Artificial Respiration
Pulmonary Hypertension
Gestational Age
Ventilation
Therapeutics
Congenital Diaphragmatic Hernias
Sildenafil Citrate

Keywords

  • Congenital diaphragmatic hernia
  • Consensus
  • Standardized treatment

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe : The CDH EURO Consortium Consensus - 2015 Update. / Snoek, Kitty G.; Reiss, Irwin K M; Greenough, A.; Capolupo, Irma; Urlesberger, Berndt; Wessel, Lucas; Storme, Laurent; Deprest, Jan; Schaible, Thomas; van Heijst, Arno; Tibboel, Dick; Allegaert, Karel; Debeer, Anne; Keijzer, R.; Benachi, Alexandra; Tissieres, P.; Kipfmueller, F.; Schaible, T.; Breatnach, C.; Patel, N.; Leva, Ernesto; Ciralli, Fabrizio; Bagolan, Pietro; Dotta, Andrea; Morini, Francesco; Di Pede, A.; Emblem, R.; Ertesvag, K.; Migdal, M.; Piotrowski, A.; Frenckner, Bjorn P.; Mesas, C.; Elorza, D.; Martínez, Leopoldo; Scharbatke, H.; Cohen-Overbeek, T.; Eggink, A. J.; Kraemer, Ulrike; Tibboel, D.; Wijnen, Rene; Deprest, J.; De Coppi, Paolo; Eaton, S.; Davenport, M.

In: Neonatology, Vol. 110, No. 1, 01.06.2016, p. 66-74.

Research output: Contribution to journalArticle

Snoek, KG, Reiss, IKM, Greenough, A, Capolupo, I, Urlesberger, B, Wessel, L, Storme, L, Deprest, J, Schaible, T, van Heijst, A, Tibboel, D, Allegaert, K, Debeer, A, Keijzer, R, Benachi, A, Tissieres, P, Kipfmueller, F, Schaible, T, Breatnach, C, Patel, N, Leva, E, Ciralli, F, Bagolan, P, Dotta, A, Morini, F, Di Pede, A, Emblem, R, Ertesvag, K, Migdal, M, Piotrowski, A, Frenckner, BP, Mesas, C, Elorza, D, Martínez, L, Scharbatke, H, Cohen-Overbeek, T, Eggink, AJ, Kraemer, U, Tibboel, D, Wijnen, R, Deprest, J, De Coppi, P, Eaton, S & Davenport, M 2016, 'Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update', Neonatology, vol. 110, no. 1, pp. 66-74. https://doi.org/10.1159/000444210
Snoek, Kitty G. ; Reiss, Irwin K M ; Greenough, A. ; Capolupo, Irma ; Urlesberger, Berndt ; Wessel, Lucas ; Storme, Laurent ; Deprest, Jan ; Schaible, Thomas ; van Heijst, Arno ; Tibboel, Dick ; Allegaert, Karel ; Debeer, Anne ; Keijzer, R. ; Benachi, Alexandra ; Tissieres, P. ; Kipfmueller, F. ; Schaible, T. ; Breatnach, C. ; Patel, N. ; Leva, Ernesto ; Ciralli, Fabrizio ; Bagolan, Pietro ; Dotta, Andrea ; Morini, Francesco ; Di Pede, A. ; Emblem, R. ; Ertesvag, K. ; Migdal, M. ; Piotrowski, A. ; Frenckner, Bjorn P. ; Mesas, C. ; Elorza, D. ; Martínez, Leopoldo ; Scharbatke, H. ; Cohen-Overbeek, T. ; Eggink, A. J. ; Kraemer, Ulrike ; Tibboel, D. ; Wijnen, Rene ; Deprest, J. ; De Coppi, Paolo ; Eaton, S. ; Davenport, M. / Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe : The CDH EURO Consortium Consensus - 2015 Update. In: Neonatology. 2016 ; Vol. 110, No. 1. pp. 66-74.
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AU - Greenough, A.

AU - Capolupo, Irma

AU - Urlesberger, Berndt

AU - Wessel, Lucas

AU - Storme, Laurent

AU - Deprest, Jan

AU - Schaible, Thomas

AU - van Heijst, Arno

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AU - Allegaert, Karel

AU - Debeer, Anne

AU - Keijzer, R.

AU - Benachi, Alexandra

AU - Tissieres, P.

AU - Kipfmueller, F.

AU - Schaible, T.

AU - Breatnach, C.

AU - Patel, N.

AU - Leva, Ernesto

AU - Ciralli, Fabrizio

AU - Bagolan, Pietro

AU - Dotta, Andrea

AU - Morini, Francesco

AU - Di Pede, A.

AU - Emblem, R.

AU - Ertesvag, K.

AU - Migdal, M.

AU - Piotrowski, A.

AU - Frenckner, Bjorn P.

AU - Mesas, C.

AU - Elorza, D.

AU - Martínez, Leopoldo

AU - Scharbatke, H.

AU - Cohen-Overbeek, T.

AU - Eggink, A. J.

AU - Kraemer, Ulrike

AU - Tibboel, D.

AU - Wijnen, Rene

AU - Deprest, J.

AU - De Coppi, Paolo

AU - Eaton, S.

AU - Davenport, M.

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