Standardizing plasma protein measurements worldwide: A challenging enterprise

Giampaolo Merlini, Søren Blirup-Jensen, A. Myron Johnson, Joanna Sheldon, Ingrid Zegers

Research output: Contribution to journalArticle


The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays in consideration of the clinical impact of specific protein measurements and their relevance in monitoring disease. We report the efforts made by the Committee on Plasma Proteins of the IFCC Scientific Division to achieve worldwide comparability in plasma protein results. We focus on the production of reference materials and the methods applied throughout their production process. Particularly, the recent characterization of ERM-DA470k/IFCC and ERM-DA472/IFCC has demonstrated that it is possible to reproduce the earlier established procedures and thereby maintain standardization. Plasma protein reference materials have had a substantial impact in improving the harmonization of patient protein results that should translate into better patient care.

Original languageEnglish
Pages (from-to)1567-1575
Number of pages9
JournalClinical Chemistry and Laboratory Medicine
Issue number11
Publication statusPublished - Nov 2010


  • Harmonization
  • Plasma Proteins
  • Reference material
  • Traceability

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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