Staphylococcal IgM enzyme-linked immunosorbent assay for diagnosis of periprosthetic joint infections

Marco Artini, Carlo Romanò, Lamberto Manzoli, Gian Luca Scoarughi, Rosanna Papa, Enzo Meani, Lorenzo Drago, Laura Selan

Research output: Contribution to journalArticle

Abstract

Delayed orthopedic joint prosthesis infections (DOJP-Is) due to staphylococci frequently result in prosthetic revision. Specific and noninvasive diagnostic tests are unavailable, and DOJP-Is are commonly diagnosed at advanced stages of disease. An enzyme-linked immunosorbent assay (ELISA) was developed to detect serum antibodies against staphylococcal slime polysaccharide antigens. Using a cutoff of 0.35 ELISA units, the test showed a specificity of 95.1% (95% confidence interval [CI], 85.4 to 98.7%) and a sensitivity of 89.7% (71.5 to 97.3%) on a sample of 90 individuals.

Original languageEnglish
Pages (from-to)423-425
Number of pages3
JournalJournal of Clinical Microbiology
Volume49
Issue number1
DOIs
Publication statusPublished - Jan 2011

ASJC Scopus subject areas

  • Microbiology (medical)

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    Artini, M., Romanò, C., Manzoli, L., Scoarughi, G. L., Papa, R., Meani, E., Drago, L., & Selan, L. (2011). Staphylococcal IgM enzyme-linked immunosorbent assay for diagnosis of periprosthetic joint infections. Journal of Clinical Microbiology, 49(1), 423-425. https://doi.org/10.1128/JCM.01836-10