Starch microsphere-induced arterial flow redistribution after occlusion of replaced hepatic arteries in patients with liver metastases

D. Civalleri, G. Scopinaro, G. Simoni, F. Claudiani, M. Repetto, F. DeCian, U. Bonalumi

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Abstract

In four patients with major anomalies of the hepatic artery undergoing intra-arterial chemotherapy, aberrant lobar vessels were ligated and catheters were inserted into the contralateral artery. Catheter perfusion scans performed early after ligation with 99mTc-macroaggregated albumin (MAA) showed a defective perfusion of the lobe supplied by the occluded artery (0.43, 0.23, 0.11, and 0.28, respectively, as compared to the contralateral lobe). Further MAA scans performed after catheter infusion of 90,000,000 parts of degradable starch microspheres (DSM) showed a near normal perfusion of the ischemic lobe (0.91, 0.96, 0.87, and 0.98). On the contrary, simple MAA scans performed in the first two patients 114 and 135 days after ligation showed a still defective arterial perfusion of the ischemic lobe (0.60, and 0.24). The DSM-induced redistribution of flow towards ischemic portions of the liver suggests a possible new role of DSM in regional treatment of liver tumors in cases with either occlusion of aberrant vessels or 'hypovascular' tumors.

Original languageEnglish
Pages (from-to)2151-2155
Number of pages5
JournalCancer
Volume58
Issue number9
Publication statusPublished - 1986

Fingerprint

Hepatic Artery
Microspheres
Starch
Perfusion
Neoplasm Metastasis
Albumins
Catheters
Liver
Ligation
Arteries
Neoplasms
Drug Therapy
degradable starch microspheres
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Civalleri, D., Scopinaro, G., Simoni, G., Claudiani, F., Repetto, M., DeCian, F., & Bonalumi, U. (1986). Starch microsphere-induced arterial flow redistribution after occlusion of replaced hepatic arteries in patients with liver metastases. Cancer, 58(9), 2151-2155.

Starch microsphere-induced arterial flow redistribution after occlusion of replaced hepatic arteries in patients with liver metastases. / Civalleri, D.; Scopinaro, G.; Simoni, G.; Claudiani, F.; Repetto, M.; DeCian, F.; Bonalumi, U.

In: Cancer, Vol. 58, No. 9, 1986, p. 2151-2155.

Research output: Contribution to journalArticle

Civalleri, D, Scopinaro, G, Simoni, G, Claudiani, F, Repetto, M, DeCian, F & Bonalumi, U 1986, 'Starch microsphere-induced arterial flow redistribution after occlusion of replaced hepatic arteries in patients with liver metastases', Cancer, vol. 58, no. 9, pp. 2151-2155.
Civalleri, D. ; Scopinaro, G. ; Simoni, G. ; Claudiani, F. ; Repetto, M. ; DeCian, F. ; Bonalumi, U. / Starch microsphere-induced arterial flow redistribution after occlusion of replaced hepatic arteries in patients with liver metastases. In: Cancer. 1986 ; Vol. 58, No. 9. pp. 2151-2155.
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