State-dependent mean-field formalism to model different activity states in conductance-based networks of spiking neurons

Cristiano Capone, Matteo di Volo, Alberto Romagnoni, Maurizio Mattia, Alain Destexhe

Research output: Contribution to journalArticlepeer-review

Abstract

More interest has been shown in recent years to large-scale spiking simulations of cerebral neuronal networks, coming both from the presence of high-performance computers and increasing details in experimental observations. In this context it is important to understand how population dynamics are generated by the designed parameters of the networks, which is the question addressed by mean-field theories. Despite analytic solutions for the mean-field dynamics already being proposed for current-based neurons (CUBA), a complete analytic description has not been achieved yet for more realistic neural properties, such as conductance-based (COBA) network of adaptive exponential neurons (AdEx). Here, we propose a principled approach to map a COBA on a CUBA. Such an approach provides a state-dependent approximation capable of reliably predicting the firing-rate properties of an AdEx neuron with noninstantaneous COBA integration. We also applied our theory to population dynamics, predicting the dynamical properties of the network in very different regimes, such as asynchronous irregular and synchronous irregular (slow oscillations). This result shows that a state-dependent approximation can be successfully introduced to take into account the subtle effects of COBA integration and to deal with a theory capable of correctly predicting the activity in regimes of alternating states like slow oscillations.

Original languageEnglish
Pages (from-to)062413
Number of pages10
JournalPhysical review. E
Volume100
Issue number6-1
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Models, Neurological
  • Computational Physics
  • Simulation methods and programs

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