State of the art in magnetic resonance imaging of hepatocellular carcinoma

Natally Horvat, Serena Monti, Brunna Clemente Oliveira, Camila Carlos Tavares Rocha, Romina Grazia Giancipoli, Lorenzo Mannelli

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Background. Liver cancer is the sixth most common cancer worldwide and the second leading cause of cancer mortality. Chronic liver disease caused by viral infection, alcohol abuse, or other factors can lead to cirrhosis. Cirrhosis is the most important clinical risk factor for hepatocellular carcinoma (HCC) whereby the normal hepatic architecture is replaced by fibrous septa and a spectrum of nodules ranging from benign regenerative nodules to HCC, each one of them with different imaging features. Multiple studies have demonstrated that magnetic resonance imaging (MRI) has excellent sensitivity and specificity for the detection and characterization of HCC in comparison with computed tomography (CT) and ultrasound. Beyond the standard protocol, the use of hepatobiliary contrast agents and the acquisition of additional sequences such as diffusion weighted imaging (DWI) with apparent diffusion coefficient mapping, subtraction imaging, multiplanar acquisition, and hepatobiliary phase, have been proposed to improve the detection of HCC, especially in the case of small, well-differentiated, and post-treatment HCC. Conclusions. Furthermore, advanced techniques including the quantification of hepatic and intralesional fat and iron, magnetic resonance elastography, radiomics, radiogenomics, and positron emission tomography (PET)-MRI are highly promising for the extraction of new imaging biomarkers that reflect the tumor microenvironment and, in the future, may add decision-making value in the management of patients with HCC.

Original languageEnglish
Pages (from-to)353-364
Number of pages12
JournalRadiology and Oncology
Volume52
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

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Hepatocellular Carcinoma
Magnetic Resonance Imaging
Fibrosis
Elasticity Imaging Techniques
Tumor Microenvironment
Second Primary Neoplasms
Liver
Virus Diseases
Liver Neoplasms
Positron-Emission Tomography
Contrast Media
Alcoholism
Liver Diseases
Decision Making
Chronic Disease
Iron
Biomarkers
Fats
Tomography
Sensitivity and Specificity

Keywords

  • Cirrhosis
  • Hepatic nodule
  • Hepatocellular carcinoma
  • Liver
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Horvat, N., Monti, S., Oliveira, B. C., Rocha, C. C. T., Giancipoli, R. G., & Mannelli, L. (2018). State of the art in magnetic resonance imaging of hepatocellular carcinoma. Radiology and Oncology, 52(4), 353-364. https://doi.org/10.2478/raon-2018-0044

State of the art in magnetic resonance imaging of hepatocellular carcinoma. / Horvat, Natally; Monti, Serena; Oliveira, Brunna Clemente; Rocha, Camila Carlos Tavares; Giancipoli, Romina Grazia; Mannelli, Lorenzo.

In: Radiology and Oncology, Vol. 52, No. 4, 01.01.2018, p. 353-364.

Research output: Contribution to journalReview article

Horvat, N, Monti, S, Oliveira, BC, Rocha, CCT, Giancipoli, RG & Mannelli, L 2018, 'State of the art in magnetic resonance imaging of hepatocellular carcinoma', Radiology and Oncology, vol. 52, no. 4, pp. 353-364. https://doi.org/10.2478/raon-2018-0044
Horvat, Natally ; Monti, Serena ; Oliveira, Brunna Clemente ; Rocha, Camila Carlos Tavares ; Giancipoli, Romina Grazia ; Mannelli, Lorenzo. / State of the art in magnetic resonance imaging of hepatocellular carcinoma. In: Radiology and Oncology. 2018 ; Vol. 52, No. 4. pp. 353-364.
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