A new traumatic model of immobilization osteoporosis in trabecular bone was studied in male adult rats by means of radiographic and histomorphometric analysis of IV tail vertebrae in ten immobilized and ten control animals. The tail was immobilized in a narrow rounded edge aluminium tube filled with low fusion point paraffin and held in place for ten days. The radiographic comparison clearly showed that the vertebral bodies excised from the immobilized tail were more transparent than those from control animals. Histomorphometric analysis revealed that in the immobilized rats there was a significant decrease in bone volume, osteoid surface and single labeled surface, associated with an increase in Eroded Surface. Mineralization rate and double labeled surface were not significantly modified between control and immobilized animals. This experiment model of tail immobilization in rats seems to be a valid model of pure disuse osteoporosis, since it enables the determination of a rapid and substantial decrease of bone volume in atraumatic conditions.
|Translated title of the contribution||Static and dynamic bone histomorphometry in a new experimental model of disuse osteopenia|
|Number of pages||6|
|Journal||Minerva Ortopedica e Traumatologica|
|Publication status||Published - 1997|
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